Choroid Thickness May Shed Light On Early Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- Choroidal thickness in Healthy Subjects
研究概览
简要总结
Purpose: To investigate any relationship between choroid thickness (CTh) and coronary artery disease (CAD), particularly in its earlier stages before clinically evident.
Design: Retrospective, cross-sectional observational study
Methods:
Setting: The study was performed in two institutions; patients were recruited in Balikesir City Hospital. The ophthalmological examinations and coronary angiograms were performed in Balikesir City Hospital. The analysis of the coronary angiograms including Gensini scoring were conducted in Bursa Education and Research Hospital.
Study Population: The study group comprised 68 patients with documented CAD and 60 healthy control subjects. Patients with high myopia, cataracts, retinal vascular disease, retinal surgery, retinal dystrophy, laser photocoagulation, intravitreal anti-VEGF treatment, glaucoma, uveitis, retinal disorders, any systemic diseases were excluded from the study groups.
Observation Procedure: Refractive examination, corrected visual acuity, intraocular pressure measurements, anterior and posterior segment examinations. Following measurements of macular thickness and retinal nerve fiber layer, choroidal thickness of both eyes was assessed by enhanced depth imaging optical coherence tomography.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal coronaries at coronary angiography for healthy control group
- •Without any coronary artery disease equivalent diseases such as peripheral artery disease, cerebrovascular disease and stroke for healthy control group
- •Ability to give informed consent for the study
- •Coronary artery disease with stenosis detected in coronary angiogram for coronary artery disease group
排除标准
- •High myopia (> 6D)
- •Cataracts
- •Retinal vascular disease
- •Retinal surgery
- •Retinal dystrophy
- •Laser photocoagulation
- •Intravitreal anti-VEGF treatment
- •Retinal disorders (comprising diabetic macular edema, diabetic/hypertensive retinopathy, vein occlusions, retinal dystrophy, epiretinal membrane, vitreomacular traction, age-related macular degeneration)
- •Any systemic diseases
- •Obesity (body-mass index ≥30 kg/m²)
结局指标
主要结局
Choroidal thickness in Healthy Subjects
时间窗: 1 day
micron
Choroidal thickness in patients with coronary artery disease
时间窗: 1 day
micron
次要结局
未报告次要终点
研究者
ERHAN TENEKECIOGLU
Assoc Prof
Bursa Yüksek İhtisas Education and Research Hospital