Serological Response to mRNA and Inactivated COVID-19 Vaccine in Health Care Workers in Hong Kong
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 480
- 试验地点
- 1
- 主要终点
- Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine
研究概览
简要总结
Since the first local case of COVID-19 confirmed on 4 Feb 2020, Hong Kong has already experienced 4 waves of COVID-19 surge, with more than 9000 cases reported. A number of vaccines have been shown to be efficacious against symptomatic and severe infection by inducing neutralizing antibody (NAB) against spike protein of the SARS-CoV-2 virus. However, the duration of protection and longevity of antibody response is unknown.
Health care workers (HCWs) who are planning to receive COVID-19 vaccine will be recruited. The level of antibody against spike protein by different quantitative assays will also be serially measured .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any staff, visiting doctor, nursing student of HKSH who are aged 18 or above
- •No contraindication for COVID-19 vaccination and plan to receive the intended dosages at the appropriate interval.
- •A baseline serology taken within 1 week before vaccination shows no evidence of recent infection.
- •No history of documented COVID-19 infection
排除标准
- 未提供
结局指标
主要结局
Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine
时间窗: 1 month, 3 months and 6 months post vaccination
Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine at different points during the first six months of vaccination
次要结局
未报告次要终点
研究者
Dr. Jonpaul ST Zee
Specialist in Infectious Disease
Hong Kong Sanatorium & Hospital