KCT0000102招募中未知
A Randomized, Multi-center, Phase IV Open-label Study to Evaluate the Long-term Effect of Carvedilol versus Propranolol on Reduction in Portal Pressure in Patients with Cirrhosis
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 130
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 20(Year) 至 70(Year)（—）
- 性别
- All
入选标准
- •(1) cirrhosis
- •(2) severe portal hypertension (hepatic venous pressure gradient > 12mmHg)
- •(3) F2/F3 varices or endoscopic treatment of large esophageal varices at least 3 months old the last time
- •(4) Child-Pugh score < 12
- •(5) not taking patients beta-blocker, ACE inhibitor, nitrate within 1 month
排除标准
- •(1) systolic blood pressure < 90 mmHg, baseline heart rate < 55/min
- •(2) refractory ascites, hepatic encephalopathy, hepatorenal syndrome
- •(3) hepatocellular carcinoma
- •(4) presence of severe systemic illness
- •(5) history of gastric variceal hemorrhage
- •(6) contraindication of beta-blocker
- •(7) serum jaundice > 10 mg/dL
- •(8) srum creatinine = 1.2 mg/dL
- •(9) history of shunt or TIPS
- •(11) pregnancy
- •(12) allergy to beta-blocker or alpha-blocker
- •(13) unwilling to sign inform consent
- •(14) Clinical investigator have determined that patient is difficult to perform the clinical trial.
研究者
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