A prospective study to evaluate the long-term effect of carvedilol versus propranolol on reduction in portal pressure in cirrhotic patients
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0000102
- Lead Sponsor
- Hanyang University Guri Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 130
(1) cirrhosis
(2) severe portal hypertension (hepatic venous pressure gradient > 12mmHg)
(3) F2/F3 varices or endoscopic treatment of large esophageal varices at least 3 months old the last time
(4) Child-Pugh score < 12
(5) not taking patients beta-blocker, ACE inhibitor, nitrate within 1 month
(1) systolic blood pressure < 90 mmHg, baseline heart rate < 55/min
(2) refractory ascites, hepatic encephalopathy, hepatorenal syndrome
(3) hepatocellular carcinoma
(4) presence of severe systemic illness
(5) history of gastric variceal hemorrhage
(6) contraindication of beta-blocker
(7) serum jaundice > 10 mg/dL
(8) srum creatinine = 1.2 mg/dL
(9) history of shunt or TIPS
(10) IDDM
(11) pregnancy
(12) allergy to beta-blocker or alpha-blocker
(13) unwilling to sign inform consent
(14) Clinical investigator have determined that patient is difficult to perform the clinical trial.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method reduction of hepatic pressure gradient
- Secondary Outcome Measures
Name Time Method compliance;incidence of variceal bleeding;the relationship between hepatic venous pressure gradinet and ultrasonographic findings