Metabolic Adaptations to Diabetes in African Americans
Not Applicable
Completed
- Conditions
- Diabetes
- Registration Number
- NCT00780195
- Lead Sponsor
- Vanderbilt University
- Brief Summary
We do not know why diabetic patients cannot protect themselves against low blood sugar. Therefore, in this study, we will perform a comprehensive assessment of the body's response to low blood sugar by measuring changes in blood hormones, blood sugar production, and nerve signals.
- Detailed Description
Morning and afternoon hypoglycemic episodes of 70, 60, or 50 mg/dl produce increased blunting of subsequent counterregulation dependent upon the depth of preceding hypoglycemia. We wanted to test this hypothesis in healthy African American individuals to determine if there is a difference in their responses to varying depths of hypoglycemia.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- Healthy males and females aged 18-40 yrs with no family history of diabetes mellitus.
- All prospective volunteers will have routine blood tests to screen for biochemical, hormonal and hematological abnormalities.
- Female volunteers will also undergo an HCG urine pregnancy test.
Exclusion Criteria
- Prior or current history of poor health
- Abnormal results following blood and physical examination
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Primary Outcome Measures
Name Time Method catecholamines 2 hours
- Secondary Outcome Measures
Name Time Method