Control and Intervention Programme on Alzheimer's Disease Risk Factors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 409
- 试验地点
- 2
- 主要终点
- Change in Short Version of the Minnesota Leisure Time Physical Activity Questionnaire
研究概览
简要总结
Recent epidemiologic studies are identifying a number of modifiable risk and protective factors that may influence in the incidence of Alzheimer's disease (AD). Therefore, the combination of an early detection of individuals at risk together with interventional studies targeted to the control of modifiable risk factors makes primary prevention programmes to become a new and real therapeutic strategy.
In this scenario, the investigators have designed the ALFAlife study, a programme of control and intervention on the modifiable AD risk factors. Throughout this study, participants will be given a number of healthy lifestyle guidelines that are personalised depending on their specific risk profile. These guidelines refer to smoking and dietary habits and physical, cognitive and social activity. The investigators hypothesis is that the follow-up of these guidelines will favor a change of participants' lifestyle habits towards healthier ones. In addition, the investigators hypothesise that changes in these lifestyle habits will have an effect on objective physiological measures (such as blood pressure and cholesterol levels).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 78 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants in the ALFA study (NCT01835717)
- •Computer literacy
- •Accept study's tests and procedures
- •Signature of informed consent
排除标准
- •Cognitive impairment assessed by clinical criteria that, according to the investigator's evaluation could interfere with the study's follow-up.
- •Anxiety or depression assessed by clinical criteria that, according to the investigator's evaluation could interfere with the study's follow-up.
- •Visual and/or hearing impairment severe enough to impede tests realization.
- •Major psychiatric or neurological disorder or other diseases that according to the investigator's evaluation could interfere with the study's follow-up.
- •Antecedents of infarction, ischemic heart disease, stroke, peripheral vascular disease, stent or aneurysm clip
结局指标
主要结局
Change in Short Version of the Minnesota Leisure Time Physical Activity Questionnaire
时间窗: 1 year; change between baseline and one year after
Change in 14-item mediterranean diet Questionnaire
时间窗: 1 year; change between baseline and one year after
Change in Lifestyle Activities Questionnaire (LAQ)
时间窗: 1 year; change between baseline and one year after
次要结局
未报告次要终点