Comparison of two different drugs through epidural for post operative pain control in knee surgeries.

Recruiting

• Conditions: Monoarthritis, not elsewhere classified,

• Registration Number: CTRI/2023/08/056823
• Lead Sponsor: kempegowda institute of medical science

Brief Summary

International association for the study of pain (IASP) defines pain as "An unpleasent sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage".Ineffectively managing pain in the postoperative period often leads to unpleasent consequences like increased cost of care, slower recovery, development of chronic pain.Postoperative pain relief can be achieved by a number of techniques such as intravenous patient controlled analgesia with Opioids,NSAIDS, peripheral local anaesthetics and epidural analgesia. Neuraxial anesthesia includes all the central blocks -  spinal, epidural, and caudal spaces. While it is an invaluable adjunct , it is now even occasionally a good alternative to general anesthesia. Knowledge about the drug used for the epidural block becomes primarily important because it affects duration, desire to have a sensory and/or motor block etc.Epidural administration of local anesthetics and opiates has proven to be effective in the treatment of intra and postoperative pain .Hence, in this sudy we will compare and determine the postoperative analgesic efficacy  of bupivacaine 0.125% with fentanyl 0.7mcg/kg  versus morphine 2mg through epidural in total knee arthroplasty cases.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-11-19
• Study Start: 2023-12-09

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Patients aged 18 to 60 years posted for elective total knee arthroplasty under combined spinal epidural.
• American Society of Anaesthesiology (ASA) physical status 1 and 2.

Exclusion Criteria

• EXCLUSION CRITERIA: a) Patient refusal for the study.
• b) Has any known allergy or contraindication to the drugs or neuraxial anaesthesia.
• c) Has received chronic opioids.
• d) Has uncontrolled diabetic mellitus,hepatic or renal impairment e) Pregnant or lactating.
• f) Duration of surgery extending to more than 4 hours.
• g) Local infection at site of injection.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to compare & determine the postoperative analgesic efficacy of bupivacaine 0.125 % with fentanyl versus morphine 2 mg through epidural in tka cases	4th hourly for 24 hours

Secondary Outcome Measures

Name	Time	Method
to estimate number of rescue analgesia required	to study the side effects of drugs when administered through epidural

Trial Locations

Locations (1)

Kempegowda Institute Of Medical Sciences; 🇮🇳 Bangalore, KARNATAKA, India

Kempegowda Institute Of Medical Sciences

🇮🇳Bangalore, KARNATAKA, India

Dr Priyanka S

Principal investigator

9844828926

priya1685@gmail.com