Role of Drug-Induced Sleep Endoscopy in Guiding Non-CPAP Therapy in Patients With Obstructive Sleep Apnea Syndrome
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Mansoura University
- Enrollment
- 35
- Locations
- 1
- Primary Endpoint
- the change in Apnea-Hypopnea Index (AHI) measured by polysomnography
Study Overview
Brief Summary
Continuous positive airway pressure (CPAP) remains the gold standard treatment for obstructive sleep apnea (OSA). However, many patients decline or fail CPAP therapy. Drug-induced sleep endoscopy (DISE) allows dynamic evaluation of upper airway collapse and may facilitate individualized non-CPAP treatment selection.
Detailed Description
Continuous positive airway pressure (CPAP) remains the gold standard treatment for obstructive sleep apnea (OSA). However, many patients decline or fail CPAP therapy. Drug-induced sleep endoscopy (DISE) allows dynamic evaluation of upper airway collapse and may facilitate individualized non-CPAP treatment selection.
DISE-guided management provides significant clinical and polysomnographic improvement in CPAP-intolerant OSA patients. Individualized, anatomy-based therapy enhances treatment precision and outcomes.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age ≥18 years
- •OSA confirmed by attended PSG
- •refusal of CPAP therapy.
Exclusion Criteria
- •Central sleep apnea
- •severe systemic illness
- •significant dental disease
- •pregnancy
- •craniofacial abnormalities
- •temporomandibular joint disorders.
Arms & Interventions
Drug-Induced Sleep Endoscopy in Obstructive Sleep Apnea
evaluate the effectiveness of DISE-guided allocation between mandibular advancement device (MAD) therapy and upper airway surgery in OSA patients who refused CPAP.
Intervention: Drug induced sleep endoscopy (Procedure)
Outcomes
Primary Outcomes
the change in Apnea-Hypopnea Index (AHI) measured by polysomnography
Time Frame: 3 months
evaluate the the change in Apnea-Hypopnea Index (AHI) measured by polysomnography from baseline to 3 months following DISE-guided allocation.
Secondary Outcomes
No secondary outcomes reported
Investigators
MohamedAbdElmoniem
Lecturer faculty of medicine
Mansoura University