Role of Drug-Induced Sleep Endoscopy in Guiding Non-CPAP Therapy in Patients With Obstructive Sleep Apnea Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- the change in Apnea-Hypopnea Index (AHI) measured by polysomnography
研究概览
简要总结
Continuous positive airway pressure (CPAP) remains the gold standard treatment for obstructive sleep apnea (OSA). However, many patients decline or fail CPAP therapy. Drug-induced sleep endoscopy (DISE) allows dynamic evaluation of upper airway collapse and may facilitate individualized non-CPAP treatment selection.
详细描述
Continuous positive airway pressure (CPAP) remains the gold standard treatment for obstructive sleep apnea (OSA). However, many patients decline or fail CPAP therapy. Drug-induced sleep endoscopy (DISE) allows dynamic evaluation of upper airway collapse and may facilitate individualized non-CPAP treatment selection.
DISE-guided management provides significant clinical and polysomnographic improvement in CPAP-intolerant OSA patients. Individualized, anatomy-based therapy enhances treatment precision and outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years
- •OSA confirmed by attended PSG
- •refusal of CPAP therapy.
排除标准
- •Central sleep apnea
- •severe systemic illness
- •significant dental disease
- •pregnancy
- •craniofacial abnormalities
- •temporomandibular joint disorders.
研究组 & 干预措施
Drug-Induced Sleep Endoscopy in Obstructive Sleep Apnea
evaluate the effectiveness of DISE-guided allocation between mandibular advancement device (MAD) therapy and upper airway surgery in OSA patients who refused CPAP.
干预措施: Drug induced sleep endoscopy (Procedure)
结局指标
主要结局
the change in Apnea-Hypopnea Index (AHI) measured by polysomnography
时间窗: 3 months
evaluate the the change in Apnea-Hypopnea Index (AHI) measured by polysomnography from baseline to 3 months following DISE-guided allocation.
次要结局
未报告次要终点
研究者
MohamedAbdElmoniem
Lecturer faculty of medicine
Mansoura University