ACTRN12618000814279已完成未知
Effects of intragastric administration of quinine (bitter agonist), on appetite and energy intake, and gut hormone release, in healthy, lean volunteers.
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 12
研究概览
简要总结
In healthy men, intragastric administration of quinine, at the administered doses, did not affect energy intake, appetite perceptions or gastrointestinal symptoms. Based on these outcomes, we decided not to measure gastrointestinal hormones.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 55 Years（—）
- 性别
- Male
入选标准
- •A total of 12 healthy, lean (BMI 19-25 kg/m2) male subjects, aged between 18 - 55 years, will be included in each study part.
排除标准
- •Significant gastrointestinal symptoms, disease or surgery;
- •Current gallbladder or pancreatic disease;
- •Cardiovascular or respiratory diseases;
- •Any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above);
- •Use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, gastrointestinal function, body weight or appetite (eg domperidone and cisapride, anticholinergic drugs (eg atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St Johns Wort etc.);
- •Individuals with low ferritin levels (less than 30 ng/mL), or who have donated blood in the 12 weeks prior to taking part in the study;
- •Lactose intolerance/other food allergy(ies);
- •Vegetarians;
- •Restrained eaters (score >12 on the three factor eating questionnaire).
- •Current intake of greater than 2 standard drinks on greater than 5 days per week;
- •Current smokers of cigarettes/cigars/marijuana;
- •Current intake of any illicit substance;
- •High performance athletes;
- •Inability to comprehend study protocol;
- •Unable to tolerate naso-gastric tube;
研究者
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