Ultrasonography Assessment of Septic Arthritis on Native Joint
- Conditions
- Septic Arthritis
- Interventions
- Other: Ultrasonography assessment
- Registration Number
- NCT02018952
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
The aim of this trial is to study the interest of ultrasonography among patients with septic arthritis.
Currently, ultrasonography is useful for detecting small fluid effusions, for examining otherwise inaccessible joints, such as the hip and for helping the joint aspiration.
Accurate assessment of disease activity and joint damage in septic arthritis is important for monitoring treatment efficiency and for prediction of the outcome of the disease.
Nowadays, magnetic resonance imaging (MRI) provides better resolution than radiography or tomography for the detection of joint effusion and for differentiation between bone and soft tissue infectious. The sensibility is reported to be nearly 100% with a specificity of more than 75%.
However, MRI is expensive and not rapidly accessible.
Therefore, ultrasonography, a non invasive, painless, inexpensive, and non radiating exam can be used to assess the presence and extent of inflammation, destruction, and tissue response.
The objective is to describe, using ultrasonography, the abnormalities joint structure influenced the septic arthritis evolution and prognosis.
The investigators hope, at the end of this study, to evaluate ultrasonography interest in septic arthritis and to establish ultrasonography prognosis factors to predict treatment efficiency and functional outcome.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
- Major patients hospitalized in Rheumatology, Infectiology, Orthopedy Department (hospital of Nantes, of La Roche sur Yon and of Saint-Nazaire) with a septic arthritis of shoulder, or elbow, or wrist , or hip, or knee, or ankle on native joint, with positive microbiologic culture joint fluid or positive hemoculture; the diagnosis was based on positive histology or imagery with an inflammatory joint fluid if the microbiologic cultures (hemoculture or joint effusion) were negative.
- Presence of material on the targeted joint
- Age < 18 years old
- Patients under guardianship
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Ultrasonography assessment Ultrasonography assessment -
- Primary Outcome Measures
Name Time Method Abnormalities joint structure influencing the septic arthritis evolution and prognosis 15 months Ultrasonography description of :
* synovium aspect : homogeneous, nodular
* maximum thickness synovium
* synovium doppler signal (grade 0, 1, 2, 3)
* presence and aspect of joint effusion : anechoic, hypo/hyperechoic, heterogeneous
* presence and aspect of bone erosions : single, minimal/deep, multiple, minimal/ deep
* presence of a synovium partitioning
* soft tissue aspect : cellulitis, myelitis
- Secondary Outcome Measures
Name Time Method Percentage of decreased range of motion relative to normal range of motion at 3 months 15 months The evolution of the abnormalities joint structure using ultrasonography 15 months To describe the evolution of ultrasonography parameters during the monitoring and to research a link between those ultrasonography parameters and prognostic indicators : ultrasonography parameters at day 0, Day 4, Day 15, and 3 months.
Return delay apyrexia 15 months To describe the evolution of ultrasonography parameters during the monitoring and to research a link between those ultrasonography parameters and prognostic indicators : Return delay apyrexia.
Measure of range of motion at 3 months 15 months Delay of surgical management 15 months To describe the evolution of ultrasonography parameters during the monitoring and to research a link between those ultrasonography parameters and prognostic indicators : Delay of surgical management.
Normalization of C Reactive Protein levels 15 months To describe the evolution of ultrasonography parameters during the monitoring and to research a link between those ultrasonography parameters and prognostic indicators : Normalization of C Reactive Protein levels.
Pain at rest measured by scale at 3 months 15 months Pain during activity measured by scale at 3 months 15 months Functional outcome score Short Form (SF) 36 at 3 months 15 months
Trial Locations
- Locations (3)
CH de Nantes
🇫🇷Nantes, France
CH Saint-Nazaire
🇫🇷Saint-Nazaire, France
CH La Roche-sur-Yon
🇫🇷La Roche-sur-Yon, France