ACTRN12626000814370RecruitingNot Applicable
Validation of Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) assays as a traumatic brain injury (TBI) prognostication marker
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 100
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (—)
- Sex
- All
Inclusion Criteria
- •Patients admitted to the ICU who:
- •Are less than 24 hours since suffering from a traumatic brain injury
- •Are expected to stay in the ICU for more than 48 hours
- •Are between 18 and 80 years old
- •Have CT brain imaging evidence of presence of traumatic brain injury
Exclusion Criteria
- •Conditions which will cause a rise or alterations in GFAP and UCH-L1 levels independent of the TBI:
- •Spinal Cord Injury (radiological evidence)
- •A known central nervous system (CNS) and/or paraneoplastic malignancy.
- •Acute Kidney Injury (Creatinine levels greater than 1.5x baseline) or End-stage renal failure (receives chronic dialysis)
- •Pre-existing neurodegenerative disease (Parkinson’s, Alzheimer’s, Lewy body, etc.)
- •Cardiac arrest / suspected hypoxic-ischaemic encephalopathy.
- •Pregnancy/lactation/=3 months postpartum
- •Massive transfusion in the previous 12 hours
- •Conditions that may interefere with the ability to assess outcomes:
- •Severe pre-existing physical or mental disability or severe comorbidity that may interfere with the assessment of outcome.
Arms & Interventions
a) Overview of information collected
Intervention: a) Overview of information collected
Investigators
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