Risk Assessment Tool for Graft Survival in Pediatric Kidney Transplantation

Completed

• Conditions: Pediatric Kidney Disease; Kidney Transplant Failure and Rejection

• Registration Number: NCT05388955
• Lead Sponsor: Radboud University Medical Center

Brief Summary

Registry study in which data of all pediatric kidney recipients in the Netherlands (registered in the Nederlandse Orgaan Transplantatie Registry) are studied to develop a risk calculator for graft loss.

Detailed Description

The pre-transplantation parameters of all recipients are used to do a multivariable regression analysis.

The B-coefficients of this analysis will be used to develop a risk calculator that predicts graft survival after transplantation per year of transplantation.

Study Timeline

• Study Start: 1966-01
• Primary Completion: 2022-01-01
• Study Completion: 2022-01-01
• Status Verified: 2022-05
• Study First Submitted: 2022-05-19
• Study First Submitted QC: 2022-05-19
• Study First Posted: 2022-05-24
• Last Update Submitted: 2023-12-03
• Last Update Posted: 2023-12-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1425

Inclusion Criteria

Pediatric kidney recipients

• transplantation in the Netherlands
• signed informed consent

Exclusion Criteria

• combined transplantation (pancreas-kidney of liver-kidney transplantation)
• No informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Graft survival	Up to 50 years after transplantation	Functioning graft of death with functioning graft. Survival graph: Percentage recipients with a functioning graft over time