Anti-inflammatory Effect of Aerobic Exercise in Individual With Increased Cardiovascular Risk
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 68
- 主要终点
- C-reactive protein
研究概览
简要总结
Aerobic physical activity attenuates systemic inflammatory activity in individuals with cardiovascular risk.
详细描述
Background: Observational studies suggest that exercise has anti-inflammatory effect, however this idea has not been definitively confirmed by randomized clinical trials.
Objective
To test the hypothesis that aerobic exercise attenuates systemic inflammatory activity in individuals with cardiovascular risk.
Methods: Randomized controlled trial, which included 68 sedentary individuals, with at least two risk factors for coronary heart disease or established cardiovascular disease. The volunteers were randomized to 3 months of supervised aerobic training or just advice when healthy lifestyles. C-reactive protein (CRP) was measured by the method of high sensitivity before and after 3 months of intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals with are between 40 to 70 years, no regular exercise, and at least two risk factor for cardiovascular disease (diabetes, hypertension, dyslipidemia, smoking) or documented cardiovascular disease.
排除标准
- •Incapacity to exercise.
结局指标
主要结局
C-reactive protein
时间窗: 3 months
次要结局
未报告次要终点
研究者
Luis CL Correia
Associate Professor of Medicine
Escola Bahiana de Medicina e Saude Publica