Sugammadex and Time to Extubation in Ophthalmic Surgery

Completed

• Conditions: General Anesthesia Using Endotracheal Intubation; Ophthalmologic Surgical Procedure; Sugammadex; Neostigmine; Extubation Readiness
• Interventions: Drug: sugammadex; Drug: Neostigmine + Atropine

• Registration Number: NCT06632067
• Lead Sponsor: China Medical University Hospital

Brief Summary

This study is to invastigate if patients treated with sugammadex compared to neostigmine/atropine would be extubate faster upon emergence of anesthesia.

Detailed Description

This is a retrospective case-control study including patients aged 18 years or older who underwent ophthalmic surgeries under general anesthesia with tracheal intubation between 2020 and 2022. Patients who received rocuronium as the sole neuromuscular blocking agent and were maintained with sevoflurane or desflurane and intravenous fentanyl were included. Based on the choice of reversal agent for neuromuscular blockade, patients were divided into two groups: the sugammadex group or the neostigmine group. Patients who underwent emergency surgery or combined surgeries with other specialties were excluded. Patient characteristics, including age, gender, ASA classification, weight, and height, were collected. Anesthesia-related medications were recorded. The time points of anesthesia induction, start and end of surgery, reversal agent administration, and tracheal extubation were documented.

Study Timeline

• Study Start: 2023-08-01
• Primary Completion: 2023-08-31
• Study Completion: 2023-08-31
• Status Verified: 2024-10
• Study First Submitted: 2024-10-06
• Study First Submitted QC: 2024-10-06
• Last Update Submitted: 2024-10-06
• Study First Posted: 2024-10-08
• Last Update Posted: 2024-10-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 262

Inclusion Criteria

aged 18 years or older ophthalmic surgeries under general anesthesia with tracheal intubation between 2020 and 2022 received rocuronium as the sole neuromuscular blocking agent maintained with sevoflurane or desflurane and intravenous fentanyl

Exclusion Criteria

emergency surgery combined surgeries with other specialties

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
sugammadex	sugammadex	those who use sugammadex for reversal of neuromuscular blockade
neostigmine	Neostigmine + Atropine	those who use neostigmine/atroping for reversal of neuromuscular blockade

Primary Outcome Measures

Name	Time	Method
Time From reversal to extubation	Time From reversal to extubation	Time From reversal to extubation
Time From the end of surgery to reversal	Time From the end of surgery to reversal	Time From the end of surgery to reversal

Secondary Outcome Measures

Name	Time	Method
Time From induction to the end of surgery	Time From induction to the end of surgery	Time From induction to the end of surgery

Trial Locations

Locations (1)

China Medical University Hospital; 🇨🇳 Taichung, Taiwan