Prospective Randomized Trial of Laparoscopic Versus Open Liver Resection for Patients With Hepatocellular Carcinoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hepatocellular Carcinoma
- Sponsor
- Seoul National University Hospital
- Enrollment
- 84
- Locations
- 1
- Primary Endpoint
- Recurrence rate
- Last Updated
- 9 years ago
Overview
Brief Summary
Short-term outcomes of laparoscopic liver resection is better than those of open liver resection
Laparoscopic liver resection is better than open resection in immunological aspects
Detailed Description
Advantages and disadvantages of the laparoscopic compared with the open approach for liver resections 1. Advantages 1) Less postoperative ascites production 2) Reduced postoperative pain 3) Feasible in selected cirrhotics who have contraindications to open surgery 4) Less intra-abdominal adhesions (easier salvage transplantation) 5) Shorter recovery time 6) Shorter length of stay 7) Reduced financial cost 2. Disadvantages 1) No manual palpation or exploration of the liver parenchyma possible (with the pure laparoscopic approach) 2) High demand in surgical skill (especially major resections)
Investigators
Ho-Seong Han
Professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Radiologically diagnosed hepatocellular carcinoma
- •Child classification A or B
- •Aged 20 to 80
- •Informed consent taken
Exclusion Criteria
- •Child classification C
- •Extrahepatic metastasis
- •Tumor located in central area or adjacent to middle hepatic vein
- •Recurred hepatocellular carcinoma
- •Critically ill patient
- •Patient with psychiatric disease
Outcomes
Primary Outcomes
Recurrence rate
Time Frame: 2 years after operation
Secondary Outcomes
- Survival(2 years after operation)