Prospective Randomized Trial of Laparoscopic Versus Open Liver Resection for HCC

Not Applicable

• Conditions: Hepatocellular Carcinoma
• Interventions: Procedure: Liver resection

• Registration Number: NCT00606385
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Short-term outcomes of laparoscopic liver resection is better than those of open liver resection

Laparoscopic liver resection is better than open resection in immunological aspects

Detailed Description

Advantages and disadvantages of the laparoscopic compared with the open approach for liver resections

1. Advantages 1) Less postoperative ascites production 2) Reduced postoperative pain 3) Feasible in selected cirrhotics who have contraindications to open surgery 4) Less intra-abdominal adhesions (easier salvage transplantation) 5) Shorter recovery time 6) Shorter length of stay 7) Reduced financial cost

2. Disadvantages 1) No manual palpation or exploration of the liver parenchyma possible (with the pure laparoscopic approach) 2) High demand in surgical skill (especially major resections)

Study Timeline

• Study Start: 2007-12
• Study First Submitted: 2008-01-21
• Study First Submitted QC: 2008-02-01
• Study First Posted: 2008-02-04
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-27
• Last Update Posted: 2016-10-28
• Primary Completion: 2017-06
• Study Completion: 2017-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• Radiologically diagnosed hepatocellular carcinoma
• Child classification A or B
• Aged 20 to 80
• Informed consent taken

Exclusion Criteria

• Child classification C
• Extrahepatic metastasis
• Tumor located in central area or adjacent to middle hepatic vein
• Recurred hepatocellular carcinoma
• Critically ill patient
• Patient with psychiatric disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
laparoscopic liver resection	Liver resection	Patients who underwent laparoscopic liver resection for HCC
open liver resection	Liver resection	Patients who underwent open liver resection for HCC

Primary Outcome Measures

Name	Time	Method
Recurrence rate	2 years after operation

Secondary Outcome Measures

Name	Time	Method
Survival	2 years after operation

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Gyeonggi-do, Korea, Republic of