The Pharmacological Basis for the Increase in Visual Time Constants Induced by Single Oral Doses of Sildenafil
试验速览
- 阶段
- 不适用
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- reaction time
研究概览
简要总结
Sildenafil and similar drugs have been used for several years to treat erectile dysfunction. It has been noticed that in some people, sildenafil causes a subtle increase in the length of time that visual images that we see are retained by the retina. It is thought that this might be due to an effect of sildenafil on inhibiting an enzyme called phosphodiesterase type 6 (PDE6) which is present in the retina. By giving single oral doses of sildenafil and a similar drug called tadalafil which has less effect on PDE6, we hypothesise that this is the mechanism of the change in vision caused by sildenafil. By performing computerised visual test, we plan to compare the effects of sildenafil, tadalafil and placebo tablets on vision in healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18-55 years
排除标准
- •Significant medical or psychiatric illness
- •Cardiac disease
- •Hyper or hypotension
- •Renal disease
- •Liver disease
- •Sickle cell anaemia
- •Multiple myeloma
- •Leukaemia
- •Bleeding disorders
- •Peyronie's disease
- •Subjects receiving prescribed medications
- •Subjects with known visual abnormalities other than refractive errors, including retinitis pigmentosa, optic neuropathy
结局指标
主要结局
reaction time
visual persistence
次要结局
未报告次要终点