The DAMA - Diet Exercise and Mammography (Dieta Attività fisica e MAmmografia) Trial: a physical activity and diet intervention trial to reduce mammographic breast density, a strong risk factor for breast cancer, in postmenopausal wome

Not Applicable

Completed

• Conditions: Change in mammographic breast density; Cancer

• Registration Number: ISRCTN28492718
• Lead Sponsor: Cancer Research and Prevention Institute (ISPO) (Italy)

Brief Summary

2014 Results article in http://www.ncbi.nlm.nih.gov/pubmed/25296586 results 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/30068518/ results (added 16/12/2020) 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/36454365/ (added 02/12/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-17
• Study Completion: 2012-12-31
• Last Update Posted: 9 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 234

Inclusion Criteria

Postmenopausal women aged 50-69 years, with a high-density mammographic pattern as routinely assessed in the local screening program by a semi-quantitative method (> 50% high-density area)

Exclusion Criteria

1. Pre- or peri-menopausal status
2. Current or recent (last 12 months) hormone replacement therapy
3. Current smokers
4. Diabetes and/or other major co-morbidities that could affect the possibility to follow the intervention protocol (major cardiovascular diseases, severe hip or knee osteoarthritis)
5. Previous diagnosis of breast cancer or other malignancies

Study & Design

• Study Type: Interventional
• Study Design: Not specified