USPIO Enhanced MR Imaging in CNS Tumours (UMIC)

Not Applicable

Recruiting

• Conditions: Vestibular Schwannoma; Glioma, Astrocytic

• Registration Number: NCT06572475
• Lead Sponsor: Northern Care Alliance NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-6-15
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Be at least 16 years old<br><br> - Have a CNS tumour suspected to be one of the defined histological types (vestibular<br> scwhannoma or low grade glioma)<br><br> - Be able to lie still for up to 1 hour comfortably<br><br> - Opinion of the treating clinician is that the patient will be able to successfully<br> complete the research imaging protocol.<br><br>Exclusion Criteria:<br><br> - Life expectancy less than 1 year<br><br> - Previous CNS radiotherapy/ stereotactic radiosurgery (SRS)<br><br> - Females who are pregnant/ breastfeeding<br><br> - Patients with an eGFR < 30ml/min<br><br> - Patients with known and documented history of iron overload/haemosiderosis/<br> haemochromatosis<br><br> - Patients with immune or inflammatory conditions e.g. systemic lupus erythematous,<br> rheumatoid arthritis<br><br> - Patients with absolute (e.g. pacemaker) and relative (anxiety or claustrophobia)<br> contraindications to MR scanning<br><br> - Patients with a history of allergic reaction to iron or dextran<br><br> - Patients with a history of allergic reaction to gadolinium contrast agents, asthma<br> or renal problems<br><br> - Patients who are unable to adequately understand verbal explanations or written<br> information given in English.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified