跳至主要内容
临床试验/NCT05932927
NCT05932927招募中不适用

Analysis of Clinical Features of Chronic Liver Disease Complicated With Hepatopulmonary Syndrome

Sun Jie1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2023年4月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
500
试验地点
1
主要终点
Proteomic results of participants

研究概览

简要总结

Hepatopulmonary syndrome (HPS) has unknown pathogenesis, limited treatment and poor prognosis. The onset of HPS is insidious and easy to be ignored. Many liver diseases such as "cirrhosis and related complications" are the core characteristics of Beijing You 'an Hospital, but the clinical characteristics of HPS patients in the center are still unclear. The investigators plan to make the diagnosis of HPS among chronic liver disease patients in the hospital according to the diagnostic criteria of HPS proposed in the Practice Guidelines of the International Society of Liver Transplantation in 2016, collect clinical data of HPS participants, evaluate the severity, analyze and summarize clinical characteristics, and conduct management and follow-up. At the same time, The investigators collect blood samples for proteomics tests. In order to improve the diagnosis and treatment level of HPS.

详细描述

At present, the mechanism of hepatopulmonary syndrome is not clear. The researchers plan to use the extracted plasma for detection, protein extraction and quality control, and then proteolytic hydrolysis, computer detection, and bioinformatics analysis.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 100 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • chronic hepatitis Agreed to venous blood collection

排除标准

  • pneumonia, pulmonary vascular disease, interstitial pulmonary disease, COPD, bronchial asthma, lung cancer and other primary pulmonary diseases, acute upper gastrointestinal bleeding.

结局指标

主要结局

Proteomic results of participants

时间窗: April 1,2024

Qualitative and quantitative analysis of proteome

次要结局

未报告次要终点

研究者

发起方
Sun Jie
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Sun Jie

Professor

Beijing YouAn Hospital

研究点 (1)

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