Role of Brain Gym exercise to improve cognition and ambulatory function in patients with Duchenne muscular dystrophy: Quasi-Experimental Study
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Mini-mental-scale examination (MMSE) for cognition and North Star Ambulatory Assessment (NSAA) for ambulatory function.
研究概览
简要总结
Duchenne muscular dystrophy (DMD) is primarily characterised by progressive muscle weakness and degeneration with climbing stairs, a waddling gait, and frequent falls. The symptoms mainly affect cognitive function and ambulation due to the involvement of dystrophin protein, which is essential for muscle and brain function. DMD patients present with these symptoms around 2–3 years of age and most patients become wheelchair dependent around 10–12 years of age and need assisted ventilation at around 20 years of age.Cognitive impairment in DMD can manifest as learning difficulties, attention deficits, and intellectual disability, while ambulatory function impairment often results from muscle weakness and progressive loss of mobility.The classification of Duchenne Muscular Dystrophy (DMD) typically involves staging the progression of the disease based on functional abilities, muscle strength, and mobility. It can be classified into early ambulatory, transitional, and late ambulatory phases, along with the advanced progression of the disease.
Brain gym exercises, also known as educational kinesiology or brain-based learning, are a set of movements and activities designed to stimulate brain function and enhance cognitive abilities. These exercises aim to integrate the body and mind, improve focus, concentration, memory, and overall learning efficiency. Hooks-ups, modified hook-ups, brain buttons, lazy 8s, ear pulls, energy yawns, calf pumps, and cross crawls with hands on shoulders are a few brain gym exercises found to be effective in patients with cognitive impairment.
Physiotherapy plays a vital role in managing the symptoms of DMD by preserving muscle function, improving mobility, and addressing respiratory complications. It includes a combination of therapeutic exercises, stretching, positioning, and respiratory interventions.Integrating brain gym exercises into physiotherapy interventions can further enhance cognitive function, ambulatory function, and motor skills, ultimately improving the quality of life for individuals living with DMD.With the evolving concept of brain gym exercises to improve cognition and function in children, the scope of brain gym exercises in DMD can be focused on this study to improve cognition and ambulatory function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 7.00 Year(s) 至 14.00 Year(s)(—)
- 性别
- All
入选标准
- •Only the Early Ambulatory stage of Duchenne Muscular Dystrophy patients Patients with FSIQ score greater than 90 (average FSIQ score or more) Parents give consent on behalf of the child in the English language, and able to speak and write in the English language.
排除标准
- •Late and Transitional stages of Duchenne Muscular Dystrophy patients Patients with FSIQ score less than 90 (below average FSIQ score or more) Parents are unable to speak and write in the English language.
结局指标
主要结局
Mini-mental-scale examination (MMSE) for cognition and North Star Ambulatory Assessment (NSAA) for ambulatory function.
时间窗: Assessment on the first day, followed by 2, 4, 8, and 16 weeks.
次要结局
- Full-scale Intelligence Quotient (FSIQ) for cognition(Assessment on the first day, followed by 2, 4, 8, and 16 weeks.)
研究者
Dr Jyoti Sharma
Galgotias University
