Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty

Not yet recruiting

• Conditions: Closed Reduction; Arthroplasty, Replacement, Hip; Length of Stay

• Registration Number: NCT07132723
• Lead Sponsor: Nordsjaellands Hospital

Brief Summary

The aim of the study is to investigate the impact of time to closed reduction on both patient related and organizational factors. These include, length of stay, hospitalization, admission to intensive care unit, rehospitalizations, delirium, all-cause mortality, infection requiring hospital contact, and cardiovascular complications. It is also intended to investigate whether different anaesthetic strategies and airway management are associated with different complication rates.

It is hypothesized that longer waiting time until reduction increase the postoperative length of stay, readmissions, and risk of complications.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-25
• Study First Submitted QC: 2025-08-11
• Last Update Submitted: 2025-08-11
• Study Start: 2025-08-20
• Study First Posted: 2025-08-20
• Last Update Posted: 2025-08-20
• Primary Completion: 2025-09-01
• Study Completion: 2025-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 3700

Inclusion Criteria

Patients will be considered eligible for inclusion if they meet all of the following criteria:

• Aged 18 years or older
• Presented to the emergency department with a dislocated total hip arthroplasty.
• Undergo closed reduction of the dislocated total hip arthroplasty in the operating theatre, with the involvement of the Department of Anesthesiology.

Exclusion Criteria

• Were primarily booked for open surgical reduction.
• Did not have a complete case log (i.e. time of admission; referral to the operation theatre; anesthesia induction; discharge, etc.) and we were unable to recreate the log using simple code rules.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Post procedure length of stay	30 days after the closed reduction	Post procedure length of stay from closed reduction until discharge from the hospital (hours)

Secondary Outcome Measures

Name	Time	Method
All-cause mortality	90 days after closed reduction	90 days all-cause mortality (Y/N)
Admissions to Intensive care unit	30 days after the closed reduction	Admissions to the intensive care unit within 30 days after the closed reduction.
Delirium during admission	From admission to discharge up to 30 days after closed reduction	Defined as diagnose of delirium (F05.x, obtained from the diagnosis codes from the given admission) or the non-planned administration of haloperidol, olanzapine, risperidone, or quetiapine (as a surrogate for new onset delirium)
Cardiovascular complications	From admission to 30 days after discharge.	Defined as diagnosed arrythmia (I47.x, I48.x, I49.x), myocardial infarction (I21.x, I22.x), cerebral ischemia (I61.x, I63.x, I64.x), hemorrhage(T81), pulmonary embolism(I26.x) or deep venous thrombosis(I80.2) (obtained from the diagnosis codes from the given admission)
Readmission	30 days after discharge	Readmission within 30 days after discharge
Acute kidney failure	Post procedure until 30 days after discharge	Defined as serum creatinine increase of more than 25 μmol/L within a period of less than 48 hours. (As a surrogate for acute kidney failure)
Infection requiring hospital contact	Post procedure until 30 days after discharge	Defined as diagnosed infection (postoperative infection (T81.4), pneumonia (J13.x-J18.x), Cystitis (N30.x, N39.0), sepsis (R65.x A40.x, A41.x), C. difficile (A04.7) obtained from the diagnose codes from the given admission) or administration of antibiotic treatment (as a surrogate for in-hospital infection

Trial Locations

Locations (1)

Department of Anesthesiology, North Zeeland Hospital; 🇩🇰 Hillerød, Denmark