The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression

Not Applicable

Completed

• Conditions: Hypertension
• Interventions: Other: Kiwi fruits; Other: Apple

• Registration Number: NCT00948363
• Lead Sponsor: Oslo University Hospital

Brief Summary

The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples. The investigators hypothesize that the increased intake lutein or other components in the kiwi fruit will enhance nitric oxide bioavailability and lead to vascular relaxation.

Detailed Description

An interesting finding in the Oslo Antioxidant Study was that intake of 3 kiwi fruits reduced blood pressure in a clinical significant manner compared to controls. The mechanism for the blood pressure reducing effect of kiwi or the responsible components are not elucidated. However, plasma lutein levels and antioxidant capacity measured by the ferric reducing antioxidant power was increased in the kiwi group. Moreover, gene expression was also altered by the increased intake of kiwi.

Study Timeline

• Study First Submitted: 2009-07-27
• Study First Submitted QC: 2009-07-28
• Study First Posted: 2009-07-29
• Study Start: 2009-08
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Status Verified: 2017-06
• Last Update Submitted: 2017-06-28
• Last Update Posted: 2017-06-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

• Systolic blood pressure 130-159 mmHg
• Diastolic blood pressure 85-99 mmHg
• Body mass index <35 kg/m2

Exclusion Criteria

• Systolic blood pressure >160 mmHg or <129 mmHg
• Diastolic blood pressure >100 mmHg or <84 mmHg
• Current use or need for blood pressure lowering medication
• Symptomatic cardiovascular disease, diabetes, renal dysfunction, psychiatric disorder, pregnancy or lactation, history of obesity surgery.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Kiwi fruits	Kiwi fruits	-
Apple	Apple	-

Primary Outcome Measures

Name	Time	Method
Blood pressure	8 weeks

Secondary Outcome Measures

Name	Time	Method
Endothelial function	8 weeks

Trial Locations

Locations (2)

Department of Preventive Cardiology; 🇳🇴 Oslo, Norway

Oslo University Hospital; 🇳🇴 Oslo, Norway