The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression in Mildly Hypertensive Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 118
- 试验地点
- 2
- 主要终点
- Blood pressure
研究概览
简要总结
The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples. The investigators hypothesize that the increased intake lutein or other components in the kiwi fruit will enhance nitric oxide bioavailability and lead to vascular relaxation.
详细描述
An interesting finding in the Oslo Antioxidant Study was that intake of 3 kiwi fruits reduced blood pressure in a clinical significant manner compared to controls. The mechanism for the blood pressure reducing effect of kiwi or the responsible components are not elucidated. However, plasma lutein levels and antioxidant capacity measured by the ferric reducing antioxidant power was increased in the kiwi group. Moreover, gene expression was also altered by the increased intake of kiwi.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systolic blood pressure 130-159 mmHg
- •Diastolic blood pressure 85-99 mmHg
- •Body mass index <35 kg/m2
排除标准
- •Systolic blood pressure >160 mmHg or <129 mmHg
- •Diastolic blood pressure >100 mmHg or <84 mmHg
- •Current use or need for blood pressure lowering medication
- •Symptomatic cardiovascular disease, diabetes, renal dysfunction, psychiatric disorder, pregnancy or lactation, history of obesity surgery.
研究组 & 干预措施
Kiwi fruits
干预措施: Kiwi fruits (Other)
Apple
干预措施: Apple (Other)
结局指标
主要结局
Blood pressure
时间窗: 8 weeks
次要结局
- Endothelial function(8 weeks)
研究者
Tor Ole Klemsdal
Chief Consultant
Oslo University Hospital