EVALUATION OF miRNA - 210 AS PROGNOSTIC BIOMARKER OF PRE-ECLAMPSIA - A CASE CONTROL STUDY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- To determine the upregulation of miRNA 210 gene in pre-eclamptic women compared to normal healthy pregnant women
研究概览
简要总结
This case-control study will be done in the Department of Obstetrics and Gynaecology B.L.D.E
(DEEMED TO BE UNIVERSITY) SHRI B M PATIL MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE, VIJAYAPURA, KARNATAKA, INDIA, Any pregnant woman with BP >=140/90mmhg with two readings measured 6 hours apart, with significant proteinuria (≥300 mg of protein in a 24-h urine specimen or ≥1+ by dipstick) following 20 weeks of gestation in a previously normotensive woman will be considered in this study as GROUP 1.
GROUP 2 - considered are the normotensive pregnant women.
The Non- hypertensive pregnant women of the same gestational age are matched with pregnant women of the same gestational age and followed up till delivery. Age shall be matched with +/- 2 years, and gestational age shall be matched with +/-1 week.
Adverse outcomes if any, in the mother and fetus shall be recorded.
The primary outcome is to determine the upregulation of miRNA 210 gene expression in pre-eclamptic women compared to normal healthy pregnant women.
To correlate the severity of pre-eclampsia inpregnant women with gene expression.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- Female
入选标准
- •1 Any pregnant woman with BP more than or equal to 140/90mmhg with two readings measured 6 hours apart with significant proteinuria (more than or equal to 300 mg of protein in a 24hr urine specimen or more than or equal to 1+ by dipstick) following 20 weeks of gestation in a previously normotensive woman 2Pregnant women age more than or equal to 18 3Singleton pregnancy 4Prenatal care at BLDE.
排除标准
- •1 Any congenital fetal malformations or chromosomal abnormalities 2 Chronic Hypertension 3 Twins with pre eclampsia 4 Renal disease with pre eclampsia 5 Cardiac disease with pre eclampsia 6 Recent infection 7 APLA Syndrome.
结局指标
主要结局
To determine the upregulation of miRNA 210 gene in pre-eclamptic women compared to normal healthy pregnant women
时间窗: 2 years
次要结局
- To correlate the severity of pre-eclampsia in pregnant women with the gene expression.(To correlate the fetal outcome with respect to fetal growth restriction, oligohydramnios, low birth weight, neonatal asphyxia, NICU admission.)