Comparison of Analgesic Effect and Postoperative Recovery of SAPB Combined With ESPB and TPB After Thoracoscopic Surgery

Not Applicable

Recruiting

• Conditions: Nerve Block; Thoracoscopic Surgery
• Interventions: Procedure: erector spinal plane combined with serratus anterior plane block

• Registration Number: NCT05538429
• Lead Sponsor: Zhangyi

Brief Summary

After thoracoscopic surgery, patients still face moderate to severe pain. How to effectively control pain and promote postoperative recovery of patients is a challenging problem. Thoracic paraspinal block is effective in controlling pain after thoracoscopic surgery, but it also carries the risk of difficulty in operation and puncture of the pleura. In recent years, erector spinal plane block and serratus anterior plane block have been used for postoperative analgesia after thoracoscopic surgery. The purpose of this study was to explore whether erector spinal plane combined with serratus anterior plane block can replace thoracic paravertebral block and provide a more complete analgesia after thoracoscopic surgery. Therefore, this study is of great clinical significance.

Detailed Description

In a double-blind randomized controlled study, investigators allocated 92 patients undergoing VATS to either SAPB Combined With ESPB or TPB, with both groups receiving otherwise standardized treatment, including multimodal analgesia. The primary outcome was 24-hr opioid consumption. Secondary outcomes included the number of survival analgesia at 1, 2, 4, 8, and 24 hours postoperatively ,VAS scores was assessed during resting and coughing statuses at 1, 2, 4, 8, and 24 hours postoperatively, pulmonary function indexes before and 1, 4, 24 hours after surgery , QOR-15 scores before and 24 hours after surgery, postoperative complications and recovery time nodes drainage tube removal time, discharge time.

Study Timeline

• Study Start: 2021-06-01
• Study First Submitted: 2022-01-27
• Status Verified: 2022-09
• Study First Submitted QC: 2022-09-10
• Last Update Submitted: 2022-09-10
• Study First Posted: 2022-09-13
• Last Update Posted: 2022-09-13
• Primary Completion: 2022-10-01
• Study Completion: 2022-11-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

1. American ASA Grade I-III;
2. Age: 18 ~ 70 years old;

3 BMI 19 ~ 28kg/m2;

4. Patients with elective thoracoscopic partial pneumonectomy under general anesthesia;

5 Informed Consent has been signed.

Exclusion Criteria

1. Use opioid analgesics on a daily basis or have a history of opioid abuse;
2. History of ipsilateral thoracotomy;
3. Allergic to any of the drugs used in the study, or have a history of drug allergy;
4. Mental or nervous system diseases, motor or sensory deficits;

5 there is coagulation dysfunction;

6. Cognitive dysfunction, unable to cooperate with research;

7. Severe renal, hepatic or cardiac dysfunction;

8. Chest wall and spine trauma, infection, deformity and other cases where nerve block cannot be performed;

9. Participated in other clinical trials within the 3 months prior to study inclusion;

10. Investigators consider other reasons unsuitable for clinical trial participants;

11. Patients refuse to participate.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TPVB	erector spinal plane combined with serratus anterior plane block	thoracic paravertebral block
ESPB&SAPB	erector spinal plane combined with serratus anterior plane block	erector spinal plane block combined with serratus anterior plane block

Primary Outcome Measures

Name	Time	Method
The dose of opioids used	24 hours after surgery	dosage of analgesic pump

Secondary Outcome Measures

Name	Time	Method
The dose of opioids used	1hour, 2hours, 4hours, 8hours and 48hours postoperatively after surgery	dosage of analgesic pump
pulmonary function indexes	Preoperative, postoperative 1hour, postoperative 4hours and postoperative 24hours	FVC (L)
Postoperative complications and recovery time nodes	follow up patients for an average of half a month	drainage tube removal time, length of stay, etc.
The number of survival analgesia	1hour, 2hours, 4hours, 8hours, 24hours and 48hours after surgery	times of rescue analgesia
VAS scores at resting and coughing state	1hour, 2hours, 4hours, 8hours, 24hours and 48hours after surgery	visual analog pain scale
QOR-15 scores	before and 24 hours after surgery	The highest score is 150,the lowest score is 0. The higher the score, the better off the patient was.

Trial Locations

Locations (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology.; 🇨🇳 Wuhan, Hubei, China