Endoscopic sclerotherapy compared with no specific treatment for the primary prevention of bleeding from oesophageal varices: a randomised controlled multicentre trial

Completed

• Conditions: iver cirrhosis; Digestive System; Liver cirrhosis

• Registration Number: ISRCTN03215899
• Lead Sponsor: Dutch Health Care Insurance Board (College voor Zorgverzekeringen) (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2003-08-13
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 166

Inclusion Criteria

1. Adults with endoscopically documented grade II, III or IV oesophageal varices
2. Absence of prior bleeding from varices
3. Evidence of active and/or progressive liver disease (e.g. as indicated by repeatedly elevated serum transaminases or increasing serum bilirubin levels or development of ascites within the past year)
4. Documented increase in the size of oesophageal varices
5. All patients gave informed consent

Exclusion Criteria

1. Use of beta-blockers and nitrates
2. Malignancy
3. Haemophilia
4. Age older than 70 - 75 years
5. No opportunity for follow-up visits

Study & Design

• Study Type: Interventional
• Study Design: Not specified