The Impact of Insufficient Sleep and Insomnia Disorder on Behavioral and Neural Markers of Emotion Regulation
概览
- 阶段
- 不适用
- 干预措施
- Normal Sleep
- 疾病 / 适应症
- Sleep
- 发起方
- Beth Israel Deaconess Medical Center
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Baseline Emotional Regulation Task with Strategy
- 状态
- 招募中
- 最后更新
- 18天前
概览
简要总结
The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control. The investigators will address and attempt to answer two questions.
(i) How do three nights of reduced sleep or a diagnosis of Insomnia Disorder affect the processing and regulation of emotional information compared to typical, undisturbed sleep? (ii) What overlapping and distinct neural mechanisms are engaged and associated with behavioral effects when attempting to process and regulate emotions in a sleep restricted state or with a clinical diagnosis of Insomnia Disorder? This study will investigate sleep's role in emotion processing and regulation. The findings will help further understanding of the role of sleep in healthy emotional functioning.
详细描述
Goal 1: How does sleep loss and clinical sleep disruption (i.e. Insomnia Disorder) impact emotion perception and emotion regulation? The investigators are interested in how chronic loss of sleep, either through artificially restricting sleep or clinically related sleep disturbance, impairs our ability to properly perceive and regulate our responses to emotional information using various emotion regulation strategies. There has been research on the effect of sleep loss on broad areas of cognition, such as attention, working memory, and reasoning ability, but the impact of long-term sleep loss on emotional processing and regulation remains largely unexplored. The investigators aim to characterize how sleep loss via experimentally reduced sleep in healthy control participants or clinical sleep disturbance in patients with Insomnia Disorder, affects the ability to accurately perceive emotion. Investigators will also investigate how it alters the intensity with which emotions are perceived, and the effect that these changes have on the ability to regulate emotional responses to these stimuli compared to healthy control participants that are allowed undisturbed sleep. Goal 2: How are changes in subjective emotional responses reflected in the neural signal and psychophysiological measures? The investigators will utilize fMRI and measures of autonomic reactivity (heart rate and skin conductance) to characterize the neural and psychophysiological responses that are associated with behavioral changes following sleep restriction or in patients with Insomnia disorder compared to healthy sleep control participants.
研究者
Tony Cunningham
Assistant Professor of Psychology in the Department of Psychiatry
Beth Israel Deaconess Medical Center
入排标准
入选标准
- •willing and able to follow the protocol
- •willing and able to meet inclusion criteria for fMRI scanning
- •willing to refrain from alcohol and recreational drugs for the duration of the protocol
- •normal or corrected to normal vision is required
排除标准
- •left-handedness or ambidexterity
- •the use of any drugs that could affect either sleep or cognitive functioning (e.g., prescription sleeping pills or antidepressants)
研究组 & 干预措施
Normal Sleep
Normal Sleep - Healthy participants are permitted normal nights of polysomnography or actigraphy recorded sleep before participating in an emotion regulation task during functional Magnetic Resonance Imaging (fMRI) scanning
Sleep Restriction
Healthy Participants are sleep restricted to 4 hours of sleep for 3 consecutive days before participating in an emotion regulation task during functional Magnetic Resonance Imaging (fMRI) scanning
干预措施: Sleep Restriction
Patients with Insomnia Disorder
Patients with Insomnia Disorder will also be recruited and will be permitted normal nights of polysomnography or actigraphy recorded sleep before participating in an emotion regulation task during functional Magnetic Resonance Imaging (fMRI) scanning
结局指标
主要结局
Baseline Emotional Regulation Task with Strategy
时间窗: Day 1
Baseline behavioral ratings to emotional stimuli with emotion regulation strategies
Reassessment of the Emotional Regulation Task with Strategy Baseline behavioral ratings to emotional stimuli with or without emotion regulation strategies
时间窗: one test in a 3-6 day window
Behavioral ratings to emotional stimuli with emotion regulation strategies following normal sleep or sleep restriction
Baseline Emotional Regulation Task without Strategy
时间窗: Day 1
Baseline behavioral ratings to emotional stimuli without emotion regulation strategies
Reassessment of the Emotional Regulation Task without Strategy Baseline behavioral ratings to emotional stimuli with or without emotion regulation strategies
时间窗: one test in a 3-6 day window
Behavioral ratings to emotional stimuli without emotion regulation strategies following normal sleep or sleep restriction
次要结局
- Functional Magnetic Resonance Imaging (fMRI)(one test in a 3-6 day window)