Coronary Artery disease SCreening in young ADult relativEs of individuals with premature Myocardial Infarction (CASCADE-MI study)

Not Applicable

• Conditions: Myocardial infarction; Coronary artery disease; Risk factors; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12624000400561
• Lead Sponsor: Curtin University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-03
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Apparently healthy first-degree relative aged 30 to 55 years of a patient with myocardial infarction at premature age (<55 years).

Exclusion Criteria

Exclusion criteria for the apparently healthy relative will include:
•History of cardiovascular disease (i.e., coronary artery disease, peripheral arterial disease, or cerebrovascular disease).
•Already taking aspirin or statin.
•History of iodinated contrast allergy/anaphylaxis.
•Known renal impairment with estimated glomerular filtration rate <45 ml/min/1.73m2.
•Unwilling or unable to provide informed consent.
•Pregnant women.

Exclusion criteria for the index case (patient) will include the following diagnoses:
•Non-atherosclerotic cause of myocardial infarction such as spontaneous coronary artery dissection, paradoxical venous thrombo-embolism, myocarditis, pericarditis, vasospasm, and Takotsubo cardiomyopathy.
•Myocardial infarction with nonobstructive coronary arteries.
•Probable or definite familial hypercholesterolaemia by the Dutch Lipid Clinic Network Criteria (score 6 or more).
•Age <18 years.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in low-density lipoprotein cholesterol (LDL-C) level at 1 year between the two arms[Blood test for lipid profile 1 year follow-up]