The Effect of Pregabalin on the Spinal Anesthesia

Not Applicable

Completed

• Conditions: Block
• Interventions: Drug: Placebo; Drug: Pregabalin

• Registration Number: NCT02690506
• Lead Sponsor: Kyungpook National University Hospital

Brief Summary

Pregabalin, an anticonvulsant is widely used for treatment of neuropathic pain. Recently, it was reported that premedication of pregabalin before general anesthesia is effective to reduce postoperative pain. Up to date, there is no study about the effect of premedication of pregabalin on the spinal anesthesia. Therefore, in this study, investigators investigate the effect of premedication of pregabalin on the spinal anesthesia.

Detailed Description

In this study, investigators investigate the effect of premedication of pregabaline 150 mg on the spinal anesthesia. Two hours before spinal anesthesia, placebo pill was administered to patients in the group C and pregabalin 150 mg was administered to patients in the group P, respectively. Time for the onset of blockade, cephalad level of analgesia and duration of analgesia were measured.

Study Timeline

• Study Start: 2016-02
• Study First Submitted: 2016-02-19
• Study First Submitted QC: 2016-02-23
• Study First Posted: 2016-02-24
• Status Verified: 2016-05
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Last Update Submitted: 2016-05-17
• Last Update Posted: 2016-05-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Patients of American Society of Anaesthesiologists Grades I and II

Read More

Exclusion Criteria

• Patients with infection at the puncture site, coagulopathy, having true hypersensitivity to drugs used, diabetes and hypertension, psychiatric and neurological diseases

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group C	Placebo	Oral placebo pill was administered 2 hours before anesthesia
Group P	Pregabalin	Oral pregabalin 150 mg was administered 2 hours before anesthesia

Primary Outcome Measures

Name	Time	Method
Duration of spinal anesthesia	24 hours after spinal anesthesia	Duration of spinal anesthesia was measured 24 after spinal anesthesia

Trial Locations

Locations (1)

Kyungpook National University Hospital; 🇰🇷 Daegu, Korea, Republic of