The Effect of Pregabalin on the Spinal Anesthesia: Randomized Controlled Placebo Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Duration of spinal anesthesia
研究概览
简要总结
Pregabalin, an anticonvulsant is widely used for treatment of neuropathic pain. Recently, it was reported that premedication of pregabalin before general anesthesia is effective to reduce postoperative pain. Up to date, there is no study about the effect of premedication of pregabalin on the spinal anesthesia. Therefore, in this study, investigators investigate the effect of premedication of pregabalin on the spinal anesthesia.
详细描述
In this study, investigators investigate the effect of premedication of pregabaline 150 mg on the spinal anesthesia. Two hours before spinal anesthesia, placebo pill was administered to patients in the group C and pregabalin 150 mg was administered to patients in the group P, respectively. Time for the onset of blockade, cephalad level of analgesia and duration of analgesia were measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of American Society of Anaesthesiologists Grades I and II
排除标准
- •Patients with infection at the puncture site, coagulopathy, having true hypersensitivity to drugs used, diabetes and hypertension, psychiatric and neurological diseases
研究组 & 干预措施
Group C
Oral placebo pill was administered 2 hours before anesthesia
干预措施: Placebo (Drug)
Group P
Oral pregabalin 150 mg was administered 2 hours before anesthesia
干预措施: Pregabalin (Drug)
结局指标
主要结局
Duration of spinal anesthesia
时间窗: 24 hours after spinal anesthesia
Duration of spinal anesthesia was measured 24 after spinal anesthesia
次要结局
未报告次要终点
研究者
Younghoon Jeon
Professor
Kyungpook National University Hospital