Olfactory Dysfunction of Rhinosinusitis - cAMP/Calcium Signaling Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 99
- 试验地点
- 1
研究概览
简要总结
The study examines the biochemistry underlying human olfaction in both normal and diseased states.
The study aims are: 1. to determine the levels of cAMP in olfactory tissue from people with chronic rhinosinusitis and other nasal disorders. 2. to correlate preoperative olfactory function with cAMP levels from biopsied olfactory tissue. 3. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using calcium imaging and 4. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using "smell-chip" technology.
详细描述
Subject will be recruited from those scheduled to have endoscopic sinus surgery and similar procedures. This study uses the tissue that would normally be discarded during the surgical process. The tissue is cultured and frozen for purposes of the following testing:
odor detection and signal transduction, cyclic adenosine monophosphate and odor detection, the role of cAMP in olfactory dysfunction, and pheromone detection.
Only tissue that would normally be discarded during the course of the surgery will be used. The study does not interfere with or change any clinical care.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects will be 18 years old and over and scheduled for one of the following:
- •endoscopic sinus surgery for chronic sinusitis
- •endoscopic transnasal approach to the pituitary for pituitary tumor removal
- •endoscopic inferior turbinectomy or septoplasty for nasal congestion
- •endoscopic repair of cerebrospinal fluid (CSF) leaks
排除标准
- •Subjects are excluded if they are unable to give informed consent or unable to complete self-administered questionnaires due to English language barrier, cognitive impairment, or severe medical conditions
研究者
Greg Davis
Assistant Professor
University of Washington