Pediatric FN Definition 2012 Bern The Impact of Lowering Fever Limits on the Rate of Fever in Chemotherapy-induced Neutropenia (FN). A Prospective Single-center Observational Study in Children and Adolescents With Cancer.

简要总结

主要结局

次要结局

• Proportion of FN with serious medical complication(until end of AB therapy for FN (estimated median, 4 days))
• Rate ratio of FN diagnosed earlier (applying LimitLow vs. LimitStandard)(until 2 weeks after last dose of chemotherapy (expected median, 6 months))
• Proportion of FN with blood cultures performed after start of antibiotics (AB) for prolonged fever(until end of AB therapy for FN (estimated median, 4 days))
• Proportion of FN with any adverse event(until end of AB therapy for FN (estimated median, 4 days))
• Serum level of cortisol(at presentation with FN (in reality))
• Rate of episodes of fever(until 2 weeks after last dose of chemotherapy (expected median, 6 months))
• Rate of emergency calls for fever(until 2 weeks after last dose of chemotherapy (expected median, 6 months))
• Proportion of FN with delayed hospital discharge for prolonged fever(until end of AB therapy for FN (estimated median, 4 days))
• Time point of empirical AB switch for prolonged fever during FN(until end of AB therapy for FN (estimated median, 4 days))
• Proportion of FN with switch of empirical AB for prolonged fever(until end of AB therapy for FN (estimated median, 4 days))
• Rate of emergency CBC with consultation for fever(until 2 weeks after last dose of chemotherapy (expected median, 6 months))
• Time point of starting empirical antifungal therapy for prolonged fever during FN(until end of AB therapy for FN (estimated median, 4 days))
• Proportion of FN with bacteremia(until end of AB therapy for FN (estimated median, 4 days))
• Proportion of FN with add-on of empirical antifungal therapy for prolonged fever(until end of AB therapy for FN (estimated median, 4 days))