Wake and Bright Light Therapy for Depression Among Admitted Patients
Overview
- Phase
- Not Applicable
- Intervention
- Single night's wake therapy
- Conditions
- Depression
- Sponsor
- Sahlgrenska University Hospital, Sweden
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- MADRS-S score reduction of 50%
- Status
- Terminated
- Last Updated
- 5 years ago
Overview
Brief Summary
A randomized controlled trial comparing wake therapy (single night) followed by bright light therapy to treatment as usual.
Investigators
Steinn Steingrimsson
MD, PhD, resident in psychiatry
Sahlgrenska University Hospital, Sweden
Eligibility Criteria
Inclusion Criteria
- •Depressive episode requiring admission to a psychiatric hospital (including unipolar and bipolar depression).
Exclusion Criteria
- •Psychotic symptoms/agitation
- •Compulsory admission
- •Confusion
- •Active substance use disorder
- •Eye disease preventing bright light therapy
Arms & Interventions
Chronobiological intervention
Single night's wake therapy followed by bright light therapy for a week as add-on treatment to treatment as usual.
Intervention: Single night's wake therapy
Chronobiological intervention
Single night's wake therapy followed by bright light therapy for a week as add-on treatment to treatment as usual.
Intervention: Bright light
Chronobiological intervention
Single night's wake therapy followed by bright light therapy for a week as add-on treatment to treatment as usual.
Intervention: Treatment as usual - inpatient care
Chronobiological intervention
Single night's wake therapy followed by bright light therapy for a week as add-on treatment to treatment as usual.
Intervention: Treatment as usual - medicine
Control
Treatment as usual including a private educational meeting in sleep hygiene.
Intervention: Treatment as usual - inpatient care
Control
Treatment as usual including a private educational meeting in sleep hygiene.
Intervention: Informative meeting
Control
Treatment as usual including a private educational meeting in sleep hygiene.
Intervention: Treatment as usual - medicine
Outcomes
Primary Outcomes
MADRS-S score reduction of 50%
Time Frame: One week
Montgomery Asberg Depression Rating Scale
Secondary Outcomes
- MADRS-S score at discharge(Participants will be followed at discharge, an expected average of 2-3 weeks)
- MADRS-S score at follow-up(10-14 weeks)
- ISI score score at discharge(Participants will be followed at discharge, an expected average of 2-3 weeks)
- ISI score score at follow-up(10-14 weeks)
- ISI score reduction of 50%(One week)
- Length of stay(The number of days between admission and discharge)
- Re-admission(10-14 weeks)
- CGI score(10-14 weeks)
- Medication use(10-14 weeks)