Piperine effect on caffeine salivary concentratio
Not Applicable
- Conditions
- Pharmacokinetics.General examination and investigation of persons without complaint and reported diagnosis
- Registration Number
- IRCT201209239271N3
- Lead Sponsor
- Babol University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
After providing adequate information to the subjects, eligible healthy volunteer will be enrolled in the study. be healthy; normal diet; not receiving microsomal enzyme inhibitor or inducer agents for at least 7 days before the study; not using black pepper for at least 7 days before the study; not using caffeine containing product 48 h before the study. Exclusion criteria: age below 18 and above 35; smoking; pregnancy; metabolic disorders; high pepper diet, receiving enzyme inhibitors or inducers.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Caffeine Saliva Concentration. Timepoint: Only once in fourth day of the study 0, 0.5, 2.5 and 5 h after taking Caffeine. Method of measurement: Using HPLC method (reverse phase; Water 25, Methanol 75, flow rate 0.8 ml/min, maximum wave length 242 nm).
- Secondary Outcome Measures
Name Time Method