Menstruatie(stoornissen) in de puberteit: het vervolg
- Conditions
- Menstrual cycle (irregularities) in adolescence, polycystic ovary synrome (PCOS), PCOS related health risks
- Registration Number
- NL-OMON20282
- Lead Sponsor
- VU University Medical Center, Department of Obstetrics and Gynaecology
- Brief Summary
van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens, and insulin. Fertil Steril 2000 Jul;74(1):49-58. <br><br> van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Insulin, androgen, and gonadotropin concentrations, body mass index, and waist to hip ratio in the first years after menarche in girls with regular menstrual cycles, irregular menstrual cycles, or oligomenorrhea. J Clin Endocrinol Metab 2000 Apr;85(4):1394-400. <br><br> van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Endocrine features of polycystic ovary syndrome in a random population sample of 14-16 year old adolescents. Hum Reprod 1999 Sep;14(9):2223-9. <br><br> van Hooff MH, van der Meer M, Lambalk CB, Schoemaker J. Variation of luteinizing hormone and androgens in oligomenorrhoea and its implications for the study of polycystic ovary syndrome. Hum Reprod 1999 Jul;14(7):1684-9. <br><br> van Hooff MH, Hirasing RA, Kaptein MB, Koppenaal C, Voorhorst FJ, Schoemaker J. The use of oral contraceptives by adolescents for contraception, menstrual cycle problems or acne. Acta Obstet Gynecol Scand 1998 Oct;77(9):898-904. van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Relationship of the menstrual cycle pattern in 14-17 year old old adolescents with gynaecological age, body mass index and historical parameters. Hum Reprod 1998 Aug;13(8):2252-60.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Participants of Original POMP study.
Not provided
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To estimate the predictive value of menstrual cycle pattern in adolescence (age 15-18 years) and presentation of polycystic ovary syndrome and polycystic ovary syndrome related subfertility, diabetes type II and cardiovascular health problems in adulthood.
- Secondary Outcome Measures
Name Time Method To estimate the predictive value of various combinations of menstrual cycle pattern, clinical and/or biochemical signs of hyperandrogenism and ultrasound pattern of the ovaries in adolescence (age 15-18 years) for<br /><br>-Menstrual cycle pattern/disturbances in adulthood <br /><br>-Fertility history/performance/treatment<br /><br>-Time to pregnancy, outcome of pregnancies<br /><br>-Metabolic and cardiovascular health problems/risk factors<br>