Exploring the metabolic profile of neuroendocrine tumors - Indol

niversitair Medisch Centrum Groningen0 个研究点目标入组 210 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•Inclusion criteria for all subjects:
•- written informed consent
•- age above 18 years
•Inclusion criteria for patients with a NET: (one of these)
•- histologically proven NET, with or without treatment for the NET
•- a diagnosis made by a dedicated NET specialist based on a combination of physical symptoms and signs, imaging and laboratory values.
•Inclusion criteria for healthy subjects:
•- Matching in age (plus or minus 3 years) and sex with one of the included NET patients.
•Data of healthy subjects could also be used from the SERT-study, if the subject meets the criteria mentioned above.

•Exclusion criteria for all subjects:
•- Use of drugs or food supplements that interact with the serotonin-metabolism; all serotonin re-uptake inhibitors, psychotrophic drugs, (other antidepressants; tricyclic antidepressants, MAO-inhibitors, mirtazapin, bupropion, venlafaxin, duloxetin, anxiolytic, antipsychotic and anticonvulsive drugs).
•- Drug abuse in the last 8 weeks.
•- Use of >= 14 alcoholic consumptions a week for women.
•- Use of >= 21 alcoholic consumptions a week for men.
•Exclusion criteria for healthy subjects:
•- Having a neuroendocrine tumor or neuroendocrine carcinoma from any grade and location in present or in history.
•- Having a malignancy.
•- Having an auto-immune disease.
•- Having an infection.
•- Having renal impairment.
•- Use of interferon.

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