NCT06010862招募中1 期
A Safety and Efficacy Clinical Study of CEA-targeted CAR-T Therapy forCEA-positive Advanced/Metastatic Malignant Solid Tumors
Chongqing Precision Biotech Co., Ltd1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2023年9月30日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Incidence of Adverse events after CEA CAR-T cells infusion [Safety and Tolerability]
研究概览
简要总结
This is a phase I clinical study to evaluate the safety and tolerability of CAR-T in patients with CEA-positive advanced/metastatic solid tumors, and to obtain the maximum tolerated dose of CAR-T and phase II Recommended dose.
详细描述
This is a single-center, double-arm, open-label study. The study plans to set up 2 groups,Intravenous infusion group have 4 dose groups, adopting a dose-escalating 3+3 design, and plan to recruit about 12 subjects with CEA-positive advanced/metastatic solid tumors.Intraperitoneal injection group have 4 dose groups, adopting a dose-escalating 3+3 design, and plan to recruit about 12 subjects with CD70-positive advanced/metastatic solid tumors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old, male or female;
- •Advanced, metastatic or recurrent malignant tumors diagnosed by histology or pathology, mainly colorectal cancer, esophageal cancer, gastric cancer, and pancreatic cancer;
- •After receiving at least second-line standard treatment failure (disease progression or intolerance, such as surgery, chemotherapy, radiotherapy, etc.) or lack of effective treatment methods;
- •Immunohistochemical staining of tumor samples within 3 months confirmed that the tumor was CEA positive (clear membrane staining, positive rate ≥ 10%); , the positive rate ≥ 10%), the serum CEA of the patient is required to exceed 10ug/L.
- •At least one assessable lesion according to RECIST 1.1 criteria;
- •ECOG score 0-2 points;
- •No serious mental disorder;
- •Unless otherwise specified, the function of the vital organs of the subject shall meet the following conditions:
- •Blood routine: white blood cells>3.0×10^9/L, neutrophils>0.8×10^9/L, lymphocytes cells>0.5×10^9/L, platelets>75×10^9/L, hemoglobin>80g/L;
- •Cardiac function: echocardiography showed cardiac ejection fraction ≥50%, and no obvious abnormality was found on electrocardiogram;
- •Renal function: serum creatinine≤2.0×ULN;
- •Liver function: ALT and AST ≤3.0×ULN (for patients with liver tumor infiltration, it can be relaxed to ≤5.0×ULN);
- •Total bilirubin≤3.0×ULN;
- •Oxygen saturation ≥95% in non-oxygen state.
- •Have apheresis or venous blood collection standards, and have no other contraindications for cell collection;
- •Subjects agree to use reliable and effective contraceptive methods for contraception within 1 year after signing the informed consent form to receiving CAR-T cell infusion (excluding rhythm contraception);
- •The patients themselves or their guardians agree to participate in this clinical trial and sign the ICF, indicating that they understand the purpose and procedures of this clinical trial and are willing to participate in the research.
排除标准
- •Those who have central nervous system metastasis or meningeal metastasis at the time of screening are judged by the investigator to be unsuitable for inclusion;
- •Participated in other clinical studies within 1 month before screening;
- •vaccinated with live attenuated vaccine within 4 weeks before screening;
- •Received the following anti-tumor treatments before screening: Received chemotherapy, targeted therapy or other experimental drug treatments within 14 days or at least 5 half-lives (whichever is shorter);
- •Active infection or uncontrollable infection requiring systemic treatment;
- •Patients with intestinal obstruction, active gastrointestinal bleeding, or a history of gastrointestinal bleeding within 3 months;
- •Except for alopecia or peripheral neuropathy, the toxicity of previous anti-tumor therapy has not improved to the baseline level or ≤ grade 1;
- •Suffering from any of the following heart diseases:
- •New York Heart Association (NYHA) stage III or IV congestive heart failure;
- •Myocardial infarction or coronary artery bypass grafting (CABG) within 6 months before enrollment;
- •Clinically significant ventricular arrhythmia, or a history of unexplained syncope (except those caused by vasovagal or dehydration);
- •History of severe non-ischemic cardiomyopathy;
- •Patients with active autoimmune disease, or other patients requiring long-term immunosuppressive therapy;
- •Suffering from other uncured malignant tumors in the past 3 years or at the same time, except cervical carcinoma in situ and basal cell carcinoma of the skin;
- •Hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) positive and peripheral blood hepatitis B virus (HBV) DNA titer test is greater than the normal range; hepatitis C virus (HCV) antibody positive and peripheral blood hepatitis C Virus (HCV) RNA test is greater than the normal range; human immunodeficiency virus (HIV) antibody positive; syphilis test positive;
- •Women who are pregnant or breastfeeding;
- •Other investigators deem it unsuitable to participate in the research.
结局指标
主要结局
Incidence of Adverse events after CEA CAR-T cells infusion [Safety and Tolerability]
时间窗: 28 days
Therapy-related adverse events were recorded and assessed according to the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE, Version 5.0)
Obtain the maximum tolerated dose of CEA CAR-T cells[Safety and Tolerability]
时间窗: 28 days
Dose-limiting toxicity after cell infusion
次要结局
- Progress-free survival(PFS) of CEA CAR-T treatment in patients with CD70-positive advanced malignancies[Effectiveness](2 years)
- TMAX of CEA CAR-T cells[Cell dynamics](3 months)
- Disease control rate of CAR-T cell preparations in CEA positive advanced malignancies [Effectiveness](3 months)
- Duration of Response (DOR) of CEA CAR-T treatment in patients with CEA-positive advanced malignancies[Effectiveness](3 months)
- Overall survival(OS)of CEA CAR-T treatment in patients with CEA-positive advanced malignancies[Effectiveness](2 years)
- CMAX of CEA CAR-T cells [Cell dynamics](3 months)
- Objective response rate (ORR) of CEA CAR-T treatment in patients with CD70-positive advanced malignancies[Effectiveness](3 months)
- AUCS of CEA CAR-T cells [Cell dynamics](3 months)
- Pharmacodynamics of CEA CAR-T cells[Cell dynamics](3 months)
研究者
研究点 (1)
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