Comparative study of therapeutic efficacy and safety of microneedling with topical minoxidil 5 percent gel versus microneedling with topical 2 percent tofacitinib gel in alopecia areata
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- 1. Reduction in SALT score
研究概览
简要总结
Alopecia areata is an autoimmune condition presenting as smooth, sharply demarcated, round patches of hair loss without atrophy with “exclamation mark hairâ€. AA is caused by an autoimmune reaction to the hair follicles due to both genetic and environmental factors. Various treatment modalities are used for AA including minoxidil, topical and systemic steroids, tacrolimus, topical dithranol, tretinoin, PUVA therapy, oral immunosuppressive drugs and contact immunotherapy. The present study is being conducted to compare the therapeutic efficacy and safety of microneedling with topical minoxidil 5% gel versus microneedling with topical 2% tofacitinib gel in limited patches of alopecia areata (upto 5 patches).
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients aged 18-50 years of age with limited patches of alopecia areata (upto 5 patches).
- •2.Patients who are willing to sign the written consent form prior to participation in the study.
排除标准
- •1.Patient having history of hypersensitivity to minoxidil or tofacitinib.
- •2.Active scalp infection.
- •3.Subjects with history of bleeding, platelet disorders.
- •4.History of uncontrolled diabetes mellitus and hypertension.
- •5.Pregnant and lactating females.
- •6.Immunocompromised patients.
结局指标
主要结局
1. Reduction in SALT score
时间窗: At the starting of the treatment, at every visit and 4 weekly for next 16 weeks.
2. Dermoscopic and photographic improvement
时间窗: At the starting of the treatment, at every visit and 4 weekly for next 16 weeks.
次要结局
- Safety of microneedling with topical minoxidil 5 percent gel versus microneedling with topical 2 percent tofacitinib gel using adverse drug reaction form(At every visit & 4 weekly for next 16 weeks.)
研究者
Dr Harmandeep Kaur
Guru Gobind Singh medical college and Hospital, Faridkot