NCT05025254招募中不适用
Deep Cognitive Endophenotyping of Parkinson's Disease: A Platform Development and Pilot Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Completion rate of cognitive test set (feasibility)
研究概览
简要总结
This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research. Thus a large part of this pilot study will be to demonstrate feasibility and reliability, and use this experience to develop a feasible protocol for ongoing research. The specific short-term objectives are:
- To establish the feasibility of performing large-scale deep cognitive phenotyping using online cognitive testing.
- To demonstrate that online neurocognitive testing is valid and reliable in a smaller sample of locally recruited participants tested both in-lab and online.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 45 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosis of Parkinson's disease by neurologist or healthy individual with no diagnosis of any neurological illness
排除标准
- •Psychotic spectrum disorders, active uncontrolled depression, advanced dementia (i.e. needing assistance with daily activities such as dressing or bathing), major stroke, major head injury, epilepsy requiring anti-seizure medications
结局指标
主要结局
Completion rate of cognitive test set (feasibility)
时间窗: Measured once, as this is a cross-sectional study (time to complete cognitive tests is estimated to be 1.5 hours)
Proportion of registered participants who complete all the cognitive testing.
次要结局
- Reliability of web-based vs in-person executive function testing (Stroop test performance)(Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart)
- Reliability of web-based vs in-person working memory testing (n-back test)(Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart)
- Reliability of web-based vs in-person reward processing testing(Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart)
- Reliability of web-based vs in-person visuospatial function testing (Trail making test performance)(Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart)
- Reliability of web-based vs in-person declarative memory testing (recognition memory)(Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart)
研究者
研究点 (1)
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