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Clinical Trials/NL-OMON38195
NL-OMON38195
Completed
Not Applicable

Immune development in early life - Immune development in early life

niversitair Medisch Centrum Utrecht0 sites205 target enrollmentTBD
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ConditionsAllergyImmune-mediated diseases100276651004743810028920

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Allergy
Sponsor
niversitair Medisch Centrum Utrecht
Enrollment
205
Status
Completed
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Observational invasive

Investigators

Sponsor
niversitair Medisch Centrum Utrecht

Eligibility Criteria

Inclusion Criteria

  • •\- Healthy term (37\-42 weeks) newborns born in the hospital on maternal indication after an uncomplicated pregnancy and delivery
  • •\- Diabetes group: Newborns from mothers with diabetes mellitus or diabetes gravidarum at risk for hypoglycaemia and who will routinely have several glucose controls in the first 24\-48 hours after birth
  • •\- Sepsis group: Newborns with a clinical diagnosed sepsis
  • •\- PCOS group: Newborns from mothers with PCOS
  • •\- CMV infection group: Preterm born children (AD\<32 weeks) with a postnatal acquired CMV infection and matched controls with similar clinical and patient characteristics but without a CMV infection

Exclusion Criteria

  • •\- Complications during pregnancy (HELLP, pre\-ecmplampsia, infection) except for the pathological conditions under investigation
  • •\- Smoking during pregnancy
  • •\- Use of immune\-modulating medication during pregnancy
  • •\- Use of antibiotics by the mother in two weeks before delivery
  • •\- Perinatal complications not related to inclusion criteria
  • •\- Prematurity (GA\<36 weeks) or dysmaturity (birth weight \< \-2 SD) except for the preterm born children in the CMV infected population or their controls
  • •\- Immunological disorders like velocardiofacial syndrome, DiGeorge syndrome
  • •\- Chromosomal disorders

Outcomes

Primary Outcomes

Not specified

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