NCT00089596已完成1 期
A Safety Study of Infusion of Ex Vivo Selectively Amplified Unrelated Cord Blood Stem Cells in Subjects With Hematological Malignancies Receiving Unrelated Cord Blood Transplantation
ViaCell8 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2004年3月1日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 8
研究概览
简要总结
This study hopes to show that specially treated umbilical cord cells, called stem cells, can be safely given to a person after they receive chemoradiation therapy or chemotherapy for their illness. During chemoradiation therapy or chemotherapy, a person loses all of the cells that are needed to make the different types of cells in their blood, including their immune system cells. These cells must be replaced in order for the blood and immune systems to work properly. Some people receive bone marrow transplants or other types of stem cell transplants to get the cells they need. CB001 is being developed as an option for people who need bone marrow transplants or other types of transplants to replace those cells. It is also being developed for people who do not have the option of other types of transplants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Do not have identical or 5/6 related matched bone marrow, peripheral blood or umbilical cord
- •Stable disease and lack of unrelated donor
- •Acute myeloid leukemia (AML) in 2nd or subsequent complete remission or first remission with high risk features
- •ALL in 2nd or subsequent remission or first remission with high risk features
- •Myelodysplastic syndrome (MDS)
- •Non-Hodgkin Lymphoma (NHL)
- •Chronic Myelogenous Leukemia (CML)
- •Adequate function of heart, liver, kidneys and lungs
排除标准
- •Females who are pregnant
- •Poor ability to perform daily activities
- •Weight under 40 kilograms (88 pounds)
- •AML caused by chemoradiation
- •Prior stem cell transplant
- •Uncontrolled infection at time of transplant
- •Active fungal infection
- •HIV infection
- •Primary myelofibrosis
- •Receiving other research drugs
- •Unable to provide informed consent
研究者
研究点 (8)
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