Defining Systemic Control of Iron Absorption to Optimize Oral Iron Supplementation Regiemns for Women With Iron Deficiency Anemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Fractional and total iron absorption
研究概览
简要总结
Iron-deficient anaemic subjects are likely to benefit most from oral iron supplements, but supplementation schedules vary widely in clinical practice, absorption is low and compliance is poor due to mild gastrointestinal side effects. The investigators will compare iron absorption from labeled oral iron doses of 100mg and 200mg administered either on two consecutive days or on alternate days in young anemic women.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Ferritin <15 µg/L
- •Hb 8-11.9 g/dl
- •BMI 18.5-24.9 kg/m2
- •Body weight <70 kg
排除标准
- •Severe anemia (Hb <8 g/dl)
- •Elevated CRP >5.0 mg/L
- •Chronic disease
- •Long-term medication, except contraception
- •Consumption of Mineral and Vitamin supplements within the study period
- •Therapeutic iron infusion over the past 6 months
- •Pregnancy or breastfeeding
结局指标
主要结局
Fractional and total iron absorption
时间窗: absorption will be measured 14days after the 100mg and 200mg cycle
Fractional and total iron absorption from different supplementation regimens
Serum EPO
时间窗: right before the administration of an iron dose
Serum EPO after the administration of different doses and using different
Serum hepcidin
时间窗: right before the administration of an iron dose
Serum hepcidin after the administration of different doses and using different regimens
次要结局
- Serum ferritin(right before the administration of an iron dose)
- Serum TfR(right before the administration of an iron dose)
- Serum CRP(right before the administration of an iron dose)
- Serum AGP(right before the administration of an iron dose)
- Serum iron(right before the administration of an iron dose)
- Total iron binding capacity(right before the administration of an iron dose)
研究者
Prof. Michael B. Zimmermann
Prof. Dr. med
Swiss Federal Institute of Technology