Effects of Rhythmic Auditory Cueing With Locomotion Training on Cortical Excitability and Behavior in Patients With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 2
- 主要终点
- Transcranial magnetic stimulation (TMS)
研究概览
简要总结
In this study, 51 subjects include 17 freezers,17 non-freezers and 17 aged-matched healthy subjects will be recruited. We will compare the cortical excitability, gait performance, and stepping-in-place performance before and after intervention of auditory cues combined with gait training. The cortical excitability will be assessed by transcranial magnetic stimulation (TMS). The purpose in this study is to investigate the effects of auditory cues with gait training on cortical excitability and rhythmic movements in patients with Parkinson's disease.
详细描述
Background: Parkinson's disease is a common neurodegenerative disease and movement disorder. Due to the degeneration of basal ganglia, patients with Parkinson's disease also demonstrate internal rhythm dysfunction, thus will lead to difficulty in rhythmic movements such as ambulation. To improve the rhythmic movement problems, auditory cues are often used in clinical setting and have been revealed providing benefits in ambulation and freezing problems for PD subjects. Besides, treadmill training is another common intervention to improve gait performance for PD. However, lack studies investigate the effects of auditory cues with locomotion training on brain neurophysiology and scarcer studies investigate the different effects of auditory cues between the freezers and non-freezers.
Objective
To investigate the effects of auditory-cued training on cortical excitability and motor performances in patients with PD. To investigate whether different effects of auditory cues on cortical excitability and motor performance between the freezers and non-freezers.
Methods: We will recruit 17 freezers, 17 non-freezers and 17 healthy elderly. Each participants will receive the trainings under two conditions in random order. There is one week wash-out period between two-trainings. Two-training are (1) treadmill training with concurrent auditory cues: participants should walk on the treadmill according to the rhythmic auditory cues (110% step frequency) for 30 min. (2) treadmill training without any auditory cues: participants should walk in comfortable speed on the treadmill for 30 min. Assessments consist of cortical excitability through transcranial magnetic stimulation (TMS), stepping-in-place test, and walking test, and they will be done before and after training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged above 20 y/o
- •Diagnosed with idiopathic Parkinson's disease
- •No hearing impairment
- •Able to walk independently without aid
- •MMSE above 24
排除标准
- •Other neurological disease
- •Orthopedic problems affect gait performance
- •Psychological disorder
- •Unstable cardiovescular and respiratory status
- •Visual disturbance affects gait performance
- •Contraindication of transcranial magnetic stimulation: family history of epilepsy; head injury; head surgery or metal implant; pacemaker; syncope or migraine with unknown reasons; pregnancy
研究组 & 干预措施
PD with freezing of gait (FOG)
Intervention will include treadmill training with auditory cues (AC) and treadmill training without auditory cues (NC).
干预措施: Treadmill training with auditory cues (Other)
PD with freezing of gait (FOG)
Intervention will include treadmill training with auditory cues (AC) and treadmill training without auditory cues (NC).
干预措施: Treadmill training without auditory cues (Other)
PD without freezing of gait (FOG)
Intervention will include treadmill training with auditory cues (AC) and treadmill training without auditory cues (NC).
干预措施: Treadmill training with auditory cues (Other)
PD without freezing of gait (FOG)
Intervention will include treadmill training with auditory cues (AC) and treadmill training without auditory cues (NC).
干预措施: Treadmill training without auditory cues (Other)
Healthy subjects (Control)
Intervention will include treadmill training with auditory cues (AC) and treadmill training without auditory cues (NC).
干预措施: Treadmill training with auditory cues (Other)
Healthy subjects (Control)
Intervention will include treadmill training with auditory cues (AC) and treadmill training without auditory cues (NC).
干预措施: Treadmill training without auditory cues (Other)
结局指标
主要结局
Transcranial magnetic stimulation (TMS)
时间窗: 40 min
TMS will be used to evaluate the cortical excitability. TMS parameters include resting motor threshold (RMT), motor evoke potential (MEPs), cortical silent period (CSP), short intracortical inhibition (SICI) and intracortical facilitation (ICF)
次要结局
- Stepping-in-place test(5 min)
- 10 meter walking test(10 min)