Validation of a Diagnostic Score for Encephalitis to Assess the Risk of Autoimmune Origin

Active, not recruiting

• Conditions: Autoimmune Encephalitis; Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder)
• Interventions: Other: Clinical score of Granillo and al.

• Registration Number: NCT05953974
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The investigators wish to test a diagnostic risk score for autoimmune encephalitis in case of encephalitis, previously validated by two American teams, in a retrospective analysis, according to the clinical and paraclinical data available in our database of the Reference Centre for Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes of Professor Honnorat for patients with NMDAr, anti LGi1, anti CASPR2, anti GABAbr and anti GAD antibodies.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-01
• Primary Completion: 2023-02-01
• Status Verified: 2023-06
• Study First Submitted: 2023-06-27
• Study First Submitted QC: 2023-07-12
• Study First Posted: 2023-07-20
• Last Update Submitted: 2023-11-09
• Last Update Posted: 2023-11-13
• Study Completion: 2023-12-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 350

Inclusion Criteria

• Age > 18 years old
• Patient with a definite auto-immune encephalitis (Graus and al. 2016)

Exclusion Criteria

• Uncomplete data in acute phase
• Patient with several antibodies
• Opposition

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
NMDAr patients	Clinical score of Granillo and al.	Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti NMDAr
CASPR2 patients	Clinical score of Granillo and al.	Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti CASPR2
GABAb patients	Clinical score of Granillo and al.	Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GABAb
LGI1 patients	Clinical score of Granillo and al.	Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti LGI1
GAD patients	Clinical score of Granillo and al.	Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GAD

Primary Outcome Measures

Name	Time	Method
Symptoms in the acute phase	At baseline
Results of lumbar puncture	At baseline
Validation of a diagnostic score for encephalitis to assess the risk of autoimmune origin.	At baseline	Comorbidities assessed by the Charlson score
Mode of onset of disease	At baseline
Results of antineuronal antibodies in CSF	At baseline
Results of antineuronal antibodies in serum	At baseline

Trial Locations

Locations (1)

Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites auto-immunes; 🇫🇷 Lyon, France