Validation of a Diagnostic Score for Encephalitis to Assess the Risk of Autoimmune Origin
Active, not recruiting
- Conditions
- Autoimmune EncephalitisAutoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder)
- Registration Number
- NCT05953974
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
The investigators wish to test a diagnostic risk score for autoimmune encephalitis in case of encephalitis, previously validated by two American teams, in a retrospective analysis, according to the clinical and paraclinical data available in our database of the Reference Centre for Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes of Professor Honnorat for patients with NMDAr, anti LGi1, anti CASPR2, anti GABAbr and anti GAD antibodies.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 350
Inclusion Criteria
- Age > 18 years old
- Patient with a definite auto-immune encephalitis (Graus and al. 2016)
Exclusion Criteria
- Uncomplete data in acute phase
- Patient with several antibodies
- Opposition
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Validation of a diagnostic score for encephalitis to assess the risk of autoimmune origin. At baseline Comorbidities assessed by the Charlson score
Mode of onset of disease At baseline Results of antineuronal antibodies in CSF At baseline Results of antineuronal antibodies in serum At baseline Symptoms in the acute phase At baseline Results of lumbar puncture At baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites auto-immunes
🇫🇷Lyon, France
Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites auto-immunes🇫🇷Lyon, France