Improved Fertility After Exercise in Overweight/Obese Women

Not Applicable

Terminated

• Conditions: Obesity; Infertility, Female
• Interventions: Behavioral: Exercise

• Registration Number: NCT01933633
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Overweight/obesity is associated with sub-fertility. The investigators will assess if regular exercise training prior to assisted fertilization will improve pregnancy rate in overweight/obese women referred to assisted fertilization. It is expected that training will be successful in increasing pregnancy rate

Detailed Description

Obesity is associated with several diseases, as type 2 diabetes, cardiovascular disease and some types of cancer, this is of great concern for the public health. Also, of more immediate importance for these women; obesity is associated with increased risks of sub-fertility. The overall aim of the current project is to expand the knowledge about effective interventions to prevent the increasing prevalence of obesity-associated sub-fertility in population.

One cause of the increased referral rate for in-vitro fertilization is the growing prevalence of overweight and obesity. Currently, about 700 couples are annually referred for in-vitro fertilization at St.Olav's Hospital. In this interdisciplinary trial, involving physiotherapists, exercise physiologists, gynecologists, and basic researchers, the effects of regular high intensity exercise training on fertility in sub-fertile overweight and obese women will be investigated.

Study Timeline

• Study First Submitted: 2013-08-28
• Study First Submitted QC: 2013-08-28
• Study Start: 2013-09
• Study First Posted: 2013-09-02
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-13
• Last Update Posted: 2018-08-15

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 18

Inclusion Criteria

• body mass index (weight in kg/height in cm squared) >25
• accepted for assisted fertilization treatment at St.Olav's hospital

Exclusion Criteria

• low responders, defined as AMH <2 pmol/L or < 5 oocytes in prior in vitro fertilisation (IVF)/Intracytoplasmic sperm injection (ICSI) cycles or antral follicle count (AFC) < 5
• current or previous Metformin use (a wash-out period of > four weeks)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	Regular exercise training for 10 weeks prior to assisted fertilisation

Primary Outcome Measures

Name	Time	Method
Pregnancy rate	7 weeks after assisted fertilisation	The primary outcome measure is ongoing pregnancy, defined as the sonographic evidence of intrauterine gestational sac and fetal heart activity at seven weeks of gestation.

Trial Locations

Locations (2)

St Olavs Hospital; 🇳🇴 Trondheim, Norway

Ålesund Hospital; 🇳🇴 Ålesund, Norway