Hepatocellular Carcinoma in HIV-infected Patients

Completed

• Conditions: Hepatitis B Virus; Liver Cirrhosis; Hepatocellular Carcinoma; HIV; Chronic Hepatitis C

• Registration Number: NCT02785835
• Lead Sponsor: Hospital Universitario de Valme

Brief Summary

Observational study. All HIV-infected patients who have been diagnosed of hepatocellular carcinoma (HCC), following the American Association for the Study of Liver Diseases (AASLD) criteria, in the participant centers are included. Epidemiological, clinical and laboratory data are collected. The clinical and epidemiological characteristics of HCC cases will be analyzed. The efficacy and outcomes after modalities of HCC therapy will be assessed. Mortality and its predictors will be also assessed. In those cases infected by hepatitis C virus (HCV), the impact of HCV therapy on outcomes will be analysed.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05
• Study First Submitted: 2016-05-25
• Study First Submitted QC: 2016-05-25
• Study First Posted: 2016-05-30
• Primary Completion: 2021-06-30
• Study Completion: 2021-06-30
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-15
• Last Update Posted: 2022-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 477

Inclusion Criteria

• HIV infection
• Diagnosis of hepatocellular carcinoma according to American Association for the Study of Liver Diseases (AASLD) criteria

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall survival	At 1 year	Overall survival after HCC diagnosis at 1 year

Trial Locations

Locations (30)

Hospital General de Castellón; 🇪🇸 Castellón De La Plana, Castellón, Spain

Hospital de San Pedro; 🇪🇸 Logroño, La Rioja, Spain

Hospital Universitario de Donostia; 🇪🇸 San Sebastián, Guipúzcua, Spain

Hospital Universitario A Coruña; 🇪🇸 A Coruna, La Coruña, Spain

Hospital de San Eloy; 🇪🇸 Barakaldo, Vizcaya, Spain

Hospital de Basurto; 🇪🇸 Basurto, Vizcaya, Spain

Hospital General Universitario de Alicante; 🇪🇸 Alicante, Spain

Hospital de Galdakao; 🇪🇸 Galdakao, Vizcaya, Spain

Hospital de Cruces; 🇪🇸 Bilbao, Vizcaya, Spain

Hospital de Puerto Real; 🇪🇸 Cádiz, Spain

Hospital Universitario Reina Sofía; 🇪🇸 Córdoba, Spain

Hospital Universitario Virgen de las Nieves; 🇪🇸 Granada, Spain

Complejo Hospitalario de Huelva; 🇪🇸 Huelva, Spain

Complejo Hospitalario de Jaén; 🇪🇸 Jaén, Spain

Hospital Universitario La Princesa; 🇪🇸 Madrid, Spain

Hospital Universitario Arrixaca; 🇪🇸 Murcia, Spain

Hospital Virgen de la Victoria; 🇪🇸 Málaga, Spain

Hospital Regional Carlos Haya; 🇪🇸 Málaga, Spain

Hospital Universitario Virgen Macarena; 🇪🇸 Sevilla, Spain

Hospital Clínico de Valencia; 🇪🇸 Valencia, Spain

Hospital General de Valencia; 🇪🇸 Valencia, Spain

Hospital Universitario y Politécnico La Fe; 🇪🇸 Valencia, Spain

Hospital de Txagorritxu; 🇪🇸 Vitoria, Álava, Spain

Hospital Universitario de Canarias; 🇪🇸 San Cristóbal de la Laguna, Santa Cruz De Tenerife, Spain

Hospital de La Linea; 🇪🇸 La Línea de la Concepción, Cádiz, Spain

Hospital German Trias i Pujol; 🇪🇸 Badalona, Barcelona, Spain

Hospital Clínico Universitario de San Juan; 🇪🇸 San Juan de Alicante, Alicante, Spain

Hospital Marina Baixa; 🇪🇸 Villajoyosa, Alicante, Spain

Hospital de Orihuela; 🇪🇸 Orihuela, Alicante, Spain

Hospital de Santa Lucía; 🇪🇸 Cartagena, Murcia, Spain