An Exploratory Randomized comparative clinical trial for the preventive effect of Denosumab versus Zoledronic acid against bone loss around femoral implants after total hip arthroplasty - An Exploratory Randomized comparative clinical trial for the preventive effect of Denosumab versus Zoledronic acid against bone loss around femoral implants after total hip arthroplasty

Yokohama City University, Orthopaedic Surgery0 个研究点目标入组 80 人开始时间: 2017年12月26日最近更新: 2023年10月17日

试验速览

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•1)Patients who have taken the following drugs for the treatment of osteoporosis: a)calcium, b)female hormone, c)activated vitamin D3, d)vitamin K, e)bisphosphonate, f)SERM, g)calcitonin, h)parathyroid hormone, PTH, i)Anti-RANKL antibody, j)Ipriflavone and k)Anabolic hormone 2)Patients diagnosed with rheumatoid arthritis; 3)Patients diagnosed with diabetes (HbA1c>7.6) within 14 days of pre-registration; 4)Patients who has/had suffered from urinary tract stones; 5)Patients who are having tooth extraction or an implant at the time of registration or during a study period; 6)Patients with liver dysfunction (GOT>36IU/L, GPT>36IU/L) within 14 days of pre-registration; 7)Patients with urinary dysfunction (creatinine clearance<35ml/min) within 14 days of pre-registration; 8)Patients with serum calcium level of less than 9.0 or more than of 10.2; 9)Patients with paralysis or a brain degenerative disease; 10)Patients with systemic infection; 11)Patients who cannot take medicine orally; 12)Patients with gastrointestinal disorder that might inhibit the absorption of medicines; 13)patients who are disqualified as sample for this research by principal and co-investigator.

发起方

Yokohama City University, Orthopaedic Surgery