Retrospective Study to Assess if Aspirin 162 mg is Better Than 81 mg for Embryo Transfer Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,207
- 试验地点
- 1
- 主要终点
- Compare clinical pregnancy rate between patients prescribed Aspirin 81 mg vs Aspirin 162 mg
研究概览
简要总结
The use of low dose aspirin is recommended for high risk patients to reduce the risk of pre-eclampsia, placental abruption and antepartum hemorrhage. Recent studies have shown that in a specific population, the use of low dose aspirin might reduce the risk of preterm birth in pregnant women with singleton pregnancy. In June 2022, clinique ovo started implementing the use of Aspirin 162 mg instead of 81 mg in the frozen embryo transfer cycles based on recent study outcomes. The use of Aspirin 162 mg might have additional benefits on the embryo transfer outcomes by decreasing the miscarriage. Moreover this can be continued until late in pregnancy without adverse effects.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 40 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women taking aspirin 81 mg or 162 mg prior to an autologous embryo transfer
- •Age < 40 years old
- •Embryo transfer cycle done at clinique ovo
排除标准
- •Egg or embryo recipient
- •History of recurrent miscarriages, defined as ≥ 3 consecutive losses
- •Patients that needed Viagra, PRP or other modalities to improve their endometrial thickness
- •Uterine factor infertility
- •Abnormal hormonal profiles
- •Stimulated embryo transfer cycles
- •History of recurrent implantation failure defined as failed ≥ 2 euploid embryos transfer or ≥ 3 blastocysts
结局指标
主要结局
Compare clinical pregnancy rate between patients prescribed Aspirin 81 mg vs Aspirin 162 mg
时间窗: Time Frame: 6 to 8 weeks after Frozen Embryo Transfer
clinical pregnancy is the presence of fetal heartbeat at the viability ultrasound
次要结局
未报告次要终点