Ovarian tissue cryopreservation as fertility preservation after childhood cancer treatment followed by long-term observation after storage.

Not Applicable

Recruiting

• Conditions: Cancer in children and AYA; Childhood cancer, CAYA

• Registration Number: JPRN-jRCT1050220005
• Lead Sponsor: Fujisaki Hiroyuki

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-04-22
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

1. Diagnose as childhood cancer or disease requiring hematopoietic stem cell transplantation.
2. Without previous chemotherapy and radiotherapy, or with previous treatments which minimally affect ovarian function.
3. Cancer treatments which expected to cause ovarian dysfunction at a high rate are planned.
4. Expected to survive 5-year after cancer treatment (Probability does not matter)
5. Not eligible for other fertility-preserving treatments.
6. One side of the ovary is retained even after ovariectomy.
7. Delay in initiation of cancer treatment due to OTC does not affect cancer outcome.
8. Written informed consent has been obtained from the patients and/or their guardians.

Exclusion Criteria

1. Clear tumor infiltration or metastasis to the ovary.
2. Severe ovarian dysfunction at the time of ovarian tissue cryopreservation because of cancer treatments, etc.
3. No uterus due to tumor resection, etc., or severe uterus dysfunction will be expected due to cancer treatments.
4. Severe neurocognitive impairment is observed or will be expected after cancer treatments.

Study & Design

• Study Type: Interventional
• Study Design: Not specified