Gene Function in Bone Marrow Cells From Patients With Fanconi Anemia and From Healthy Participants
- Conditions
- Fanconi Anemia
- Registration Number
- NCT00896740
- Lead Sponsor
- OHSU Knight Cancer Institute
- Brief Summary
RATIONALE: Studying samples of bone marrow from patients with Fanconi anemia and from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to Fanconi anemia.
PURPOSE: This laboratory study is evaluating gene function in bone marrow cells from patients with Fanconi anemia and from healthy participants.
- Detailed Description
OBJECTIVES:
* Describe the complete hematopoietic transcriptomes of Fanconi cells of every common complementation group (e.g., A, C, G, and F) as well as transcriptomes of neoplastic cells derived from bone marrow of patients with Fanconi anemia.
* Define large-scale dynamic gene expression data in these patients.
OUTLINE: This is a multicenter study.
Patients and healthy volunteers undergo bone marrow aspiration or biopsy for biological studies. Samples are analyzed for gene expression profiles using microarray assays.
PROJECTED ACCRUAL: A total of 80 patients and 10 healthy volunteers will be accrued for this study.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 90
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of FA cells from different complementation groups Comparison of Fanconi anemia (FA) hematopoietic cells vs normal hematopoietic cells Comparison of FA hematopoietic cells from children with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) vs children (siblings) with FA but without MDS/AML
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Knight Cancer Institute at Oregon Health and Science University
🇺🇸Portland, Oregon, United States