NCT00786305已完成2 期
Assessment of Efficiency of Nebulized Ceftazidime and Amikacin in Treatment of Ventilator Associated Pneumonia Caused by Pseudomonas Aeruginosa
Groupe Hospitalier Pitie-Salpetriere1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2004年10月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Bacterial killing
研究概览
简要总结
Pseudomonas aeruginosa is one of the major causative microorganisms of ventilator-associated pneumonia often resistant to antibiotics. In experimental models, nebulization of antibiotics delivers high lung tissue concentrations of antibiotics in infected lungs and increases lung bacterial killing. The aim of the study is to assess the efficiency of nebulized ceftazidime and amikacin in the treatment of pneumonia caused by Pseudomonas aeruginosa in ventilated patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female >18 years old, ventilator associated pneumonia caused by pseudomonas aeruginosa
- •Written informed consent provided by the relatives
排除标准
- •Pseudomonas aeruginosa resistant to ceftazidime and amikacin
- •Pseudomonas aeruginosa pneumonia associated with other infections requiring intravenous treatment
- •Severe septic shock and severe hypoxemia
- •Allergy to ceftazidime or amikacin
研究组 & 干预措施
1: nebulized ceftazidime and amikacin
Experimental
干预措施: ceftazidime and amikacin (Drug)
2: intravenous ceftazidime and amikacin
Active Comparator
干预措施: ceftazidime and amikacin (Drug)
结局指标
主要结局
Bacterial killing
时间窗: 14 days
次要结局
- Changes of lung aeration(8 days)
研究者
研究点 (1)
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